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首页> 外文期刊>Journal of Allergy >Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma
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Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma

机译：整合素和GPCR串扰在哮喘ASM收缩信号调节中的作用

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Airway hyperresponsiveness (AHR) is one of the cardinal features of asthma. Contraction of airway smooth muscle (ASM) cells that line the airway wall is thought to influence aspects of AHR, resulting in excessive narrowing or occlusion of the airway. ASM contraction is primarily controlled by agonists that bind G protein-coupled receptor (GPCR), which are expressed on ASM. Integrins also play a role in regulating ASM contraction signaling. As therapies for asthma are based on symptom relief, better understanding of the crosstalk between GPCRs and integrins holds good promise for the design of more effective therapies that target the underlying cellular and molecular mechanism that governs AHR. In this paper, we will review current knowledge about integrins and GPCRs in their regulation of ASM contraction signaling and discuss the emerging concept of crosstalk between the two and the implication of this crosstalk on the development of agents that target AHR.
机译：气道高反应性（AHR）是哮喘的主要特征之一。气道壁内衬的气道平滑肌（ASM）细胞收缩被认为会影响AHR的各个方面，从而导致气道过度变窄或闭塞。 ASM收缩主要受与G蛋白偶联受体（GPCR）结合的激动剂控制，该受体在ASM上表达。整联蛋白还在调节ASM收缩信号传导中起作用。由于哮喘的治疗是基于症状缓解，因此更好地了解GPCR与整联蛋白之间的串扰为设计更有效的治疗方法提供了良好的前景，这些治疗方法针对控制AHR的潜在细胞和分子机制。在本文中，我们将回顾有关整合素和GPCR在调节ASM收缩信号中的最新知识，并讨论两者之间出现的串扰概念，以及这种串扰对靶向AHR的药物发展的影响。

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