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Cytoplasmic modulators of integrin regulation/signaling

机译:整合素调节/信号传导的细胞质调节剂

摘要

The present invention provides purified and isolated polynucleotides encoding IRP polypeptides which regulate 2 and 7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes.
机译:本发明提供了编码IRP多肽的纯化和分离的多核苷酸,所述IRP多肽调节 2 7 整联蛋白,并预期参与整联蛋白的信号传导和/或再循环途径。还提供了鉴定IRP活性调节剂的方法和鉴定与IRP多肽在信号传导途径中相互作用的其他蛋白质的方法。预期IRP相互作用的调节剂可用于例如监测和治疗涉及白细胞的炎症过程。

著录项

  • 公开/公告号US2003044958A1

    专利类型

  • 公开/公告日2003-03-06

    原文格式PDF

  • 申请/专利权人 ICOS CORPORATION;

    申请/专利号US20010817513

  • 发明设计人 DONALD E. STAUNTON;BRIAN P. LISPKY;

    申请日2001-03-26

  • 分类号C07H21/04;C12N9/64;C12P21/02;C12N5/06;

  • 国家 US

  • 入库时间 2022-08-22 00:07:56

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