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Use of Animal Models to Investigate Major Allergens Associated with Food Allergy

机译：使用动物模型调查与食物过敏相关的主要过敏原

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Food allergy is an emerging epidemic that affects all age groups, with the highest prevalence rates being reported amongst Western countries such as the United States (US), United Kingdom (UK), and Australia. The development of animal models to test various food allergies has been beneficial in allowing more rapid and extensive investigations into the mechanisms involved in the allergic pathway, such as predicting possible triggers as well as the testing of novel treatments for food allergy. Traditionally, small animal models have been used to characterise immunological pathways, providing the foundation for the development of numerous allergy models. Larger animals also merit consideration as models for food allergy as they are thought to more closely reflect the human allergic state due to their physiology and outbred nature. This paper will discuss the use of animal models for the investigation of the major food allergens; cow's milk, hen's egg, and peanut/other tree nuts, highlight the distinguishing features of each of these models, and provide an overview of how the results from these trials have improved our understanding of these specific allergens and food allergy in general.
机译：食物过敏是一种影响所有年龄段的新兴流行病，据报道，西方国家（如美国（US），英国（UK）和澳大利亚）的患病率最高。用于测试各种食物过敏的动物模型的开发有利于允许对过敏途径涉及的机制进行更快速和广泛的研究，例如预测可能的诱因以及测试食物过敏的新疗法。传统上，小动物模型已用于表征免疫途径，为开发多种过敏模型奠定了基础。大型动物还应考虑作为食物过敏的模型，因为它们的生理特性和近交特性使其被认为更紧密地反映了人类的过敏状态。本文将讨论使用动物模型调查主要食物过敏原;牛奶，鸡蛋和花生/其他坚果，强调了每种模型的显着特征，并概述了这些试验的结果如何改善了我们对这些具体过敏原和食物过敏的总体认识。

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