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首页> 外文期刊>Journal of Behavioral and Brain Science >Sex-Dependent Effects of Prenatal Stress on Learned Helplessness and Anxiety-Related Behaviours in Wistar Rats
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Sex-Dependent Effects of Prenatal Stress on Learned Helplessness and Anxiety-Related Behaviours in Wistar Rats

机译：产前应激对Wistar大鼠学习性无助和焦虑相关行为的性别依赖性影响

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There has been an increasing importance of studies that link sex to stress coping processes. Recently, we reported that male and female Wistar rats responded differently to prenatal stress (PS) under basal conditions. The aim of the present study was to determine the influence of sex on behaviour and coping strategies, as an effect of gestational adversity in rats that were exposed to an uncontrollable stressor. Once the animals reached adulthood, the offspring from stressedon-stressed dams were subjected or not to antidepressant treatment with Sertraline. After that, they were exposed to a single inescapable shock (IS) session, in which the rats were further tested for escape behaviour along 10 days, as a model of learned helplessness (LH). In prenatally stressed animals after the IS, behavioural differences appeared in a sex specific manner. Males proved to be more susceptible to the adverse context than females, exhibiting behavioural despair in a large percentage of the cases. Surprisingly, PS did not affect shock escape failure, but did affect learning performance in a sex dependent manner. In females, PS led them to learn to avoid shocks, learning better than controls, and by contrast, PS males did not learn to avoid shocks and displayed some signs of anhedonia. Sertraline did not help animals to avoid shocks, but helped them to escape from it. Our data indicate the existence of sex dependent behavioural differences in PS animals when facing an uncontrollable stress situation, in which the changes induced by PS were not only different, but opposite between sexes.
机译：将性与压力应对过程联系起来的研究越来越重要。最近，我们报道了雄性和雌性Wistar大鼠在基础条件下对产前压力（PS）的反应不同。本研究的目的是确定性别对行为和应对策略的影响，作为妊娠逆境对暴露于不可控制压力的大鼠的影响。当动物成年后，对受应激/无应激水坝的后代进行舍曲林抗抑郁治疗或不进行抗抑郁治疗。之后，将他们暴露于一次不可避免的休克（IS）阶段，在该过程中，将大鼠作为学习型无助（LH）的模型，在10天之内进一步测试其逃避行为。在IS后的产前应激动物中，行为差异以性别特定的方式出现。事实证明，男性比女性更容易受到不利影响，在大多数情况下表现出行为绝望。令人惊讶的是，PS不会影响休克逃逸失败，但会以性别相关的方式影响学习成绩。在雌性动物中，PS导致他们学会避免电击，学习得比控制者要好，相反，PS男性却没有学会避免电击并表现出一些快感不足。舍曲林并没有帮助动物避免电击，而是帮助它们逃脱了。我们的数据表明，在面对无法控制的压力情况时，PS动物存在性别依赖性的行为差异，其中PS引起的变化不仅是不同的，而且在性别之间是相反的。

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