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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Age Stratification and Impact of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid Ratios in Ischemic Stroke Patients
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Age Stratification and Impact of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid Ratios in Ischemic Stroke Patients

机译：缺血性卒中患者的年龄分层和二十碳五烯酸和二十二碳六烯酸与花生四烯酸的比率的影响

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Aim : We focused on the ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to arachidonic acid (AA) and explored the significance of these ratios relative to clinical characteristics by age in ischemic stroke patients. Methods : We enrolled patients with acute ischemic stroke who underwent radiological investigations and laboratory examinations, including measurement of serum EPA, DHA, and AA levels, and controls. Patients were classified according to age (＜65, 65–74, and ≥ 75 years) and the tertile of EPA/AA and DHA/AA ratios, and clinical aspects were compared with these factors. Results : We analyzed 373 patients (age 70.2±13.4 years; 245 males) and 105 controls. Among stroke patients, patients aged ＜65 years had the lowest EPA/AA (0.35±0.23, p =0.006) and DHA/AA (0.73±0.27, p ＜0.001) ratios. Compared with controls, patients aged ＜65 years showed lower EPA/AA (vs. 0.49±0.25, p ＜0.001) and DHA/AA (vs. 0.82±0.26, p =0.009) ratios. From logistic regression analysis, the EPA/AA (odds ratio 0.18, 95% confidence interval 0.04–0.81, p =0.026) and DHA/AA (odds ratio 0.09, 95% confidence interval 0.02–0.33, p ＜0.001) ratios were inversely related to patients aged ＜65 years. According to age-stratified analyses, we found an association of aortic arch calcification with a lower EPA/AA ratio for patients aged ≥ 75 years and an association of multiple infarctions and cerebral white matter lesions with a lower EPA/AA ratio for patients aged 65–74 years ( p ＜0.05). Conclusions : The ratios of EPA/AA and DHA/AA could be specific markers for younger stroke patients. The EPA/AA ratio may be related to aortic arch calcification for elderly stroke patients and to multiple infarctions and cerebral white matter disease for middle-aged stroke patients.
机译：目的：我们关注二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）与花生四烯酸（AA）的比率，并探讨这些比率相对于缺血性卒中患者的年龄特征与临床特征的关系。方法：我们招募了接受了放射学检查和实验室检查的急性缺血性中风患者，包括血清EPA，DHA和AA水平的测定以及对照。根据年龄（＜65岁，65-74岁和≥75岁）以及EPA / AA和DHA / AA比率的三分位数对患者进行分类，并将临床方面与这些因素进行比较。结果：我们分析了373例患者（年龄70.2±13.4岁;男245例）和105例对照。在卒中患者中，＜65岁的患者的EPA / AA（0.35±0.23，p = 0.006）和DHA / AA（0.73±0.27，p ＜0.001）比率最低。与对照组相比，＜65岁的患者显示出较低的EPA / AA（vs. 0.49±0.25，p ＜0.001）和DHA / AA（vs. 0.82±0.26，p = 0.009）。通过逻辑回归分析，EPA / AA（奇数比为0.18，95％置信区间为0.04-0.81，p = 0.026）和DHA / AA（奇数比为0.09，95％置信区间为0.02-0.33，p ＜0.001）成反比与＜65岁的患者有关。根据年龄分层分析，我们发现≥75岁的患者主动脉弓钙化与较低的EPA / AA比相关，而对于65岁的患者，多发梗塞和脑白质病变与较低的EPA / AA比相关–74年（p ＜0.05）。结论：EPA / AA和DHA / AA的比例可能是年轻卒中患者的特异性指标。 EPA / AA比可能与老年卒中患者的主动脉弓钙化有关，而与中年卒中患者的多发梗塞和脑白质疾病有关。

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