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首页> 外文期刊>Journal of Applied Life Sciences International >An Epidemiological Study of Antibiotic Resistance of Salmonella typhi and Salmonella paratyphi - A from Clinical Samples in Dhaka City
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An Epidemiological Study of Antibiotic Resistance of Salmonella typhi and Salmonella paratyphi - A from Clinical Samples in Dhaka City

机译：达卡市临床样本中鼠伤寒沙门氏菌和副伤寒沙门氏菌的耐药性流行病学研究

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Aims: Typhoid fever is a serious bacterial disease caused by Salmonella typhi or Salmonella paratyphi. Study Design: The objectives of this study is to determine the prevalence and antibiotic resistance pattern of Salmonella typhi and Salmonella paratyphi isolated from adults and children presenting with symptoms at different hospital in Dhaka from 1st September-31st December 2013. Materials and Methods: The antibiotic susceptibility of 106 clinical isolates collected from blood samples was identified. Susceptibility pattern was tested by Kirby-Bauer disc diffusion method using 8 regularly used antibiotics. The patients were categorized in different 9 age groups. Data analysis was performed by using Statistical Package for Social Science (SPSS version 10.0). Results: A total of 1178 blood samples were analyzed in this study. Among which 106 showed positive result, 9% patients were ill, the causative agents- Salmonella typhi was found to be most prevalent (73.58%) followed by Salmonella paratyphi (26.42%). Result of the susceptibility test showed that the isolates were resistant to antibiotics; Nalidixic Acid and Azithromycin (79.49%) and 62(79.49%) for S. typhi isolates, 27(96.43%) and 27(96.43%) for S. paratyphi isolates respectively. Conclusion: Our study revealed high prevalence of and (100%) of MDR Salmonella isolates. This is a serious health problem in the region under study and should be prevented by some effective measure such as eating safely prepared foods and get vaccinated (Ty21a) are recommendable for the treatment of typhoid fever in this community.
机译：目的：伤寒是由伤寒沙门氏菌或副伤寒沙门氏菌引起的一种严重的细菌性疾病。研究设计：本研究的目的是确定9月1日至31日在达卡不同医院从出现症状的成年人和儿童中分离出的伤寒沙门氏菌和副伤寒沙门氏菌的患病率和抗生素耐药性模式。 sup> s 2013年12月。材料与方法：鉴定了从血液样本中收集的106株临床分离株的抗生素敏感性。使用8种常用抗生素通过Kirby-Bauer椎间盘扩散法测试药敏模式。将患者分为不同的9个年龄组。使用社会科学统计软件包（SPSS 10.0版）进行数据分析。结果：本研究共分析了1178个血液样本。其中106例呈阳性结果，9％的患者患病，其中伤寒沙门氏菌最为常见（73.58％），其次是副伤寒沙门氏菌（26.42％）。药敏试验结果表明，分离株对抗生素有抗药性。伤寒沙门氏菌分离物的萘啶酸和阿奇霉素（79.49％）和62（79.49％），副伤寒沙门氏菌分离物分别为27（96.43％）和27（96.43％）。结论：我们的研究表明，沙门氏菌MDR分离株和MDR分离株的流行率很高（100％）。在研究中的地区，这是一个严重的健康问题，应通过一些有效措施加以预防，例如，食用安全准备的食物并接种疫苗（Ty21a），建议在该社区治疗伤寒。

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