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首页> 外文期刊>The Journal of automatic chemistry >Flow-Injection Preconcentration of Chloramphenicol Using Molecularly Imprinted Polymer for HPLC Determination in Environmental Samples
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Flow-Injection Preconcentration of Chloramphenicol Using Molecularly Imprinted Polymer for HPLC Determination in Environmental Samples

机译：使用分子印迹聚合物对氯霉素进行流动注射富集以测定环境样品中的HPLC

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摘要

The residue of antibiotic chloramphenicol (CAP) is important issue for food quality control and also for the environmental monitoring. It is banned for use in food-producing animals and has very limited use in human medicine, because of its severe impact on human health. Determination of trace level of CAP in environmental samples requires a very sensitive analytical method and efficient preconcentration procedure. CAP can be efficiently preconcentrated in flow-injection system using flow-through reactor packed with molecularly imprinted polymer (MIP), but determination of CAP in eluate from MIP requires the application of chromatographic separation, which was made in reversed-phase HPLC system with UV detection. In optimized conditions the limit of detection for 100?mL sample in HPLC with offline preconcentration on MIP was evaluated as 0.66?mg/L. In hyphenated FIA-HPLC system with zone sampling the LOD for developed method was evaluated as 15?ng/L, which indicates the possibility of using it for analysis of environmental samples.
机译：抗生素氯霉素（CAP）的残留对于食品质量控制和环境监测而言都是重要的问题。由于其对人类健康的严重影响，它被禁止用于生产食物的动物，并且在人类医学中的应用非常有限。测定环境样品中痕量CAP的方法需要非常灵敏的分析方法和有效的预富集程序。可以使用装有分子印迹聚合物（MIP）的流通式反应器在流动注射系统中对CAP进行有效的预浓缩，但是测定MIP洗脱液中的CAP则需要进行色谱分离，这是在具有UV的反相HPLC系统中进行的。检测。在优化的条件下，采用MIP离线预浓缩的HPLC中100？mL样品的检出限为0.66？mg / L。在带区域采样的联用FIA-HPLC系统中，所开发方法的LOD评估为15？ng / L，这表明使用它进行环境样品分析的可能性。

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