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首页> 外文期刊>Journal of Applied Life Sciences International >Proposed Mechanisms of Suppression of B Cells by nTregs: B Cells as Targets for Suppressive Activity of nTregs
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Proposed Mechanisms of Suppression of B Cells by nTregs: B Cells as Targets for Suppressive Activity of nTregs

机译:拟议的nTregs抑制B细胞的机制:B细胞作为nTregs抑制活性的目标。

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B cells have an important role in immune system due to their role in positive and negative regulation of immune response. As positive regulators, B cells can give rise to antibody-producing plasma cells, are critical cellular adjuvants that facilitate optimal CD4+ T-cell activation. B cells also contribute to immunoregulation through the production of cytokines including IL-4, IL-6, IL-10, interferon-gamma (IFN-gamma) and transforming growth factor-β (TGF-β). In addition, B cells are thought to have specific roles in stimulating Ag-specific CD4+ T-cell proliferation after activation by dendritic cells (DCs). While B cells can play negative regulatory roles during immune responses, particularly during inflammation, autoimmunity, cancer and infection. On the other hand, natural occurring regulatory T cells (nTregs) consider a body guard of immune system and play a pivotal role in the maintenance of homeostasis of immune system and tolerance to self-antigens and tissue graft. nTregs know all languages of the immune system cells and can chat successfully with any abnormal case that happen due to aberration of function of the immune cells. nTregs can use multiple mechanisms to exert their functions. In the current review we will focus on the mechanisms of suppression of B cells by nTregs.
机译:B细胞在免疫系统的正向和负向调节中起着重要的作用。作为正调节剂,B细胞可产生抗体产生性浆细胞,是促进最佳CD4 + T细胞活化的关键细胞佐剂。 B细胞还通过产生包括IL-4,IL-6,IL-10,干扰素-γ(IFN-γ)和转化生长因子-β(TGF-β)在内的细胞因子来促进免疫调节。另外,认为B细胞在被树突状细胞(DC)激活后,在刺激Ag特异性CD4 + T细胞增殖中具有特定作用。虽然B细胞在免疫反应期间,尤其是在炎症,自身免疫,癌症和感染过程中可以发挥负调控作用。另一方面,天然存在的调节性T细胞(nTregs)则是免疫系统的保镖,在维持免疫系统的动态平衡以及对自身抗原和组织移植物的耐受性方面起着关键作用。 nTregs知道免疫系统细胞的所有语言,并且可以成功应对由于免疫细胞功能异常而发生的任何异常情况。 nTreg可以使用多种机制来发挥其功能。在当前的审查中,我们将专注于nTregs抑制B细胞的机制。

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