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首页> 外文期刊>Journal of Behavioral and Brain Science >Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase
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Restraint Induces Sickness Responses Independent of Injection with Epstein-Barr Virus (EBV)-Encoded dUTPase

机译：克制剂诱导疾病反应，独立于用爱泼斯坦-巴尔病毒（EBV）编码的dUTPase注射

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Most adult humans have been infected by Epstein-Barr virus (EBV), a putative cause of chronic fatigue syndrome, and carry latent EBV. The EBV-encoded dUTPase can induce sickness responses in mice and chronic stress exacerbates this response. Because individuals often adapt to chronic stress, we tested the hypothesis that acute restraint stress would potentiate these sickness responses elicited by EBV-encoded dUTPase. Male CD-1 mice were injected daily for one or three days with either saline or EBV-encoded dUTPase. Additionally, mice from each condition were either restrained for three hours daily or left undisturbed during the light phase when mice are inactive. Restraint decreased weight gain during the one- and three-day experiments. Restraint in saline injected mice increased anxiety-like behavior in the open field during the three-day experiment. There were no behavioral differences during the one-day experiment. Restraint stress had no effect when experienced acutely on one day, but did produce a sickness response after three days of exposure regardless of saline or dUTPase injection. In contrast to the effects of chronic stress and EBV-encoded dUTPase on the sickness response, acute stress did not affect sickness responses in association with EBV-encoded dUTPase. Thus, dUTPase does not appear to provoke the same sickness responses after acute stress as compared to chronic stress.
机译：大多数成年人类已被爱泼斯坦-巴尔病毒（EBV）感染，这是慢性疲劳综合症的推定原因，并携带潜在的EBV。 EBV编码的dUTPase可以在小鼠中诱发疾病反应，而慢性应激会加剧这种反应。因为个体经常适应慢性应激，所以我们检验了以下假设的假设：急性束缚应激会增强由EBV编码的dUTPase引起的这些疾病反应。每天给雄性CD-1小鼠注射1或3天的盐水或EBV编码的dUTPase。此外，每种情况下的小鼠每天禁食三个小时，或者在小鼠不活动时在光照阶段不受干扰。禁忌在1天和3天的实验中减少了体重增加。在为期三天的实验中，对注射盐水的小鼠进行的约束增加了旷野中的焦虑样行为。一日实验期间没有行为差异。约束压力在一天中急性发作时没有作用，但暴露三天后不管生理盐水或dUTPase注射如何，都会产生疾病反应。与慢性应激和EBV编码的dUTPase对疾病反应的影响相反，急性应激不会与EBV编码的dUTPase相关地影响疾病反应。因此，与慢性应激相比，dUTPase在急性应激后似乎不会引起相同的疾病反应。

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