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首页> 外文期刊>Journal of Behavioral and Brain Science >Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response
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Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response

机译：慢性身体压力不能与爱泼斯坦-巴尔病毒（EBV）编码的Duppase相互作用，以改变疾病反应

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Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.
机译：大多数成年人感染了爱泼斯坦-巴尔病毒（EBV），据认为该病毒有助于慢性疲劳综合症的发展。众所周知，压力会影响免疫系统，并加剧疾病反应。尽管已经确定了心理压力在疾病反应中的作用，尤其是与EBV编码的脱氧尿苷三磷酸核苷酸水解酶（dUTPase）结合使用，而物理压力在这些相互作用中的作用仍未确定。在这项研究中，我们试图确定慢性身体（游泳）压力与EBV编码的dUTPase注射的相互作用。我们假设长期的生理压力会加重EBV编码的dUTPase注射后的疾病反应。为了检验该假设，小鼠每天接受EBV编码的dUTPase或媒介注射，每天承受15分钟的游泳压力，持续14天或不进行任何操作。在注射的最后一个晚上，对小鼠进行行为测试。单独使用EBV编码的dUTPase注射会产生某些疾病行为。身体游泳压力不会改变疾病反应。

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