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首页> 外文期刊>Journal of Behavioral and Brain Science >Adolescent and Adult Circadian Rhythm Activity Modulated Differently Following Chronic Methylphenidate Administration
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Adolescent and Adult Circadian Rhythm Activity Modulated Differently Following Chronic Methylphenidate Administration

机译：长期服用哌醋甲酯后青少年和成人的昼夜节律活动受到不同的调节

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Methylphenidate is one of the most common pharmaceutical treatments for Attention Deficit Hyperactive Disorder (ADHD). It is also gaining popularity as a cognitive enhancement and recreational substance. The current study assesses the long-term effects of methylphenidate (MPD) on the circadian rhythm activity pattern of adolescent and adult male Sprague-Dawley (SD) rats. The experiment lasted for 11 days of non-stop recording, the evaluation was divided into 4 phases: acute, induction, washout, and expression phases. Circadian rhythm changes in each phase were compared between the adolescent and adult rats using the following parameters MESOR (midline estimating statistic of rhythm) or average activity, amplitude (distance from MESOR to the peak activity), and acrophase (time at which peak amplitude occurs). Overall, more significant changes in circadian rhythm pattern among adult rats were observed as compared to adolescent rats. As the circadian rhythm governs the diurnal locomotor activity pattern, changes in the locomotor pattern induced by chronic treatment MPD indicate that the drug exerts a long-term effect on the circadian rhythm.
机译：哌醋甲酯是注意力缺陷多动障碍（ADHD）的最常见药物治疗之一。作为认知增强和娱乐性物质，它也越来越受欢迎。本研究评估了哌醋甲酯（MPD）对青春期和成年雄性Sprague-Dawley（SD）大鼠昼夜节律活动模式的长期影响。实验持续11天不间断记录，评估分为四个阶段：急性，诱导，洗脱和表达阶段。使用以下参数MESOR（中线估计心律统计量）或平均活动度，振幅（从MESOR到峰值活动度的距离）和顶峰相（峰值振幅发生的时间），比较青春期和成年大鼠各阶段的昼夜节律变化）。总体而言，与青春期大鼠相比，在成年大鼠中观察到昼夜节律模式的更显着变化。由于昼夜节律控制着昼夜运动活动模式，因此由慢性治疗MPD引起的运动规律改变表明该药物对昼夜节律具有长期影响。

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