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首页> 外文期刊>Journal of Behavioral and Brain Science >Differential Effect of Acute Stress on Visuospatial Working Memory and Sexual Motivation in Male Rats
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Differential Effect of Acute Stress on Visuospatial Working Memory and Sexual Motivation in Male Rats

机译：急性应激对雄性大鼠视觉空间工作记忆和性动机的差异影响

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Working memory is an executive function that is highly dependent on the functioning of the prefrontal cortex. Several studies using food or drink as rewards have demonstrated that rats are capable of performing tasks that involve working memory. Sexual behavior is another highly-rewarding, motivated behavior that has proven to be an efficient incentive in classical operant tasks. Considering that both sexual behavior and working memory are sensitive to the effects of stress, the aim of this study was to determine the effect of acute stress on visuospatial working memory during a sexually-motivated task (a nonmatching-to-sample task in a T-maze) in male rats. Thirty-two male Wistar rats were trained in the T-maze using sexual interaction (intromission and ejaculation) as a reinforcer during a 4-day training period (training sessions held every 4th day). On the basis of their performance, the rats were classified as good-learners (n = 12) and bad-learners (n = 20), and on the fifth day, 6 good-learners and 10 bad-learners were subjected to stress using the cold water immersion model (CWI, 15°C) for 15 minutes before they were evaluated in the T-maze. The remaining rats made up the control group (i.e., they performed the task without previous stress). Results showed that acute stress by CWI improved working memory in the bad-learners but did not affect the performance of the good-learners, although in both groups (good- and bad-learners) stress decreased the sexual motivation to perform the task. It is probable that the increased levels of corticosterone in the stress situation could activate glutamatergic transmission in the prefrontal cortex, thus facilitating working memory and, simultaneously, decreasing testosterone levels, which exerts a negative effect on sexual motivation in these male rats.
机译：工作记忆是一种执行功能，高度依赖于前额叶皮层的功能。多项以食物或饮料为奖励的研究表明，大鼠能够执行涉及工作记忆的任务。性行为是另一种高度奖励的动机行为，已被证明是经典操作任务中的一种有效激励。考虑到性行为和工作记忆均对压力的影响敏感，因此本研究的目的是确定性动机任务（T型中与样本不匹配的任务）期间急性压力对视觉空间工作记忆的影响。 -迷宫）。在为期4天的训练期间（每4天训练一次），使用性相互作用（内射和射精）作为增强剂，对32只Wistar大鼠进行了T型迷宫训练。根据他们的表现，将大鼠分为好学习者（n = 12）和差学习者（n = 20），并在第五天，分别对6名好学习者和10名坏学习者进行压力训练。将其浸入冷水模型（CWI，15°C）中15分钟，然后在T型迷宫中对其进行评估。其余大鼠组成对照组（即，他们在没有事先压力的情况下执行了任务）。结果表明，CWI的急性压力可以改善学习不良的人的工作记忆，但不会影响学习良好的人的表现，尽管在两组（学习好和学习不良的人）中，压力都会降低执行任务的性动机。应激状态下皮质酮水平升高可能会激活前额叶皮层中的谷氨酸能传递，从而促进工作记忆，同时降低睾丸激素水平，这对这些雄性大鼠的性动机产生负面影响。

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