• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Behavioral and Brain Science >Hyperactivity and Abnormal Exploratory Activity Developing in CD-1 Male Mice under Chronic Experience of Aggression and Social Defeats
【24h】

Hyperactivity and Abnormal Exploratory Activity Developing in CD-1 Male Mice under Chronic Experience of Aggression and Social Defeats

机译：慢性侵略和社会挫败经历下CD-1雄性小鼠的过度活跃和探索性活动异常。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic social defeat stress induces diverse effects in mice of different strains and even in animals of the same strain. This paper aims to study the effect of repeated social defeats and, for contrast, repeated aggression in daily agonistic interactions on the behaviors of CD-1 male mice. The behavior of animals that have the same winning and losing track record during 3, 10, 21 days is studied in different tests. The level of aggressiveness, as estimated by the number and total time of attacks, decreases; nevertheless, direct and indirect forms of aggression demonstrated by the aggressive mice (winners) remain significantly high. The number of stereotypic behaviors (rotations and jumps) and total time of digging behaviors are significantly increased in the winners after 21 days compared to 3 and 10 days of intermale confrontations. Among the losers, chronic experience of social defeats is accompanied by the development of pronounced anxiety and a depression-like state estimated by the elevated plus-maze and the Porsolt test scores, respectively. Both groups of male mice with alternative social behaviors demonstrate abnormal locomotor and exploratory behaviors in the open-field test. This phenomenon may be viewed as hyperactivity developed under chronic agonistic interactions and specific for the outbred CD-1 mice. We believe that these animals may be potentially used for modeling the key symptoms of bipolar disorder.
机译：慢性社交挫败压力在不同品系的小鼠中甚至在相同品系的动物中引起多种作用。本文旨在研究反复社交挫败的影响，以及与之形成对比的是，日常激动互动中的反复攻击对CD-1雄性小鼠的行为。在不同的测试中研究了在3、10、21天内具有相同的获胜和失败记录的动物的行为。根据攻击的次数和总时间估计，攻击程度降低;但是，侵略性小鼠（优胜者）表现出的直接和间接侵略形式仍然很高。与男性间对抗的3天和10天相比，获奖者在21天后的刻板行为（旋转和跳跃）的次数和挖掘行为的总时间显着增加。在失败者中，社交失败的长期经历伴随着明显的焦虑感的发展，并分别通过升高的迷宫和波索尔特（Polsolt）考试成绩来估计抑郁状态。两组具有替代性社交行为的雄性小鼠在野外试验中均显示出异常的运动和探索行为。可以将这种现象视为在慢性激动相互作用下发展而来的多动症，它对远亲CD-1小鼠具有特异性。我们认为，这些动物可能潜在地用于建模躁郁症的关键症状。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号