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首页> 外文期刊>Journal of Behavioral and Brain Science >Intrauterine Exposure to Chronic 22 kHz Sound Affects Inhibitory Avoidance and Serotonergic Parameters in Forebrain Areas of Dams and Rat Offspring
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Intrauterine Exposure to Chronic 22 kHz Sound Affects Inhibitory Avoidance and Serotonergic Parameters in Forebrain Areas of Dams and Rat Offspring

机译：宫内暴露于慢性22 kHz声音会影响大坝和大鼠后代前脑区的抑制回避和血清素能参数。

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In the present study we evaluated the effects of chronic exposure to sounds at 22 kHz during pregnancy on the central serotonergic and behavioral parameters in Wistar rat dams after the suckling period and on their male rat offspring. In addition, we also assessed the effects of an acute 22 kHz sound, associated with the chronic intrauterine exposure, on the emotional responses of adult offspring. The primary hypothesis was that experiencing 22 kHz stimuli during an early stage of development would interfere with brain serotonergic parameters and, later, with the adult rat’s defensive responses. The corollary question was whether a 22 kHz sound exposure would differentially affect inhibitory avoidance and escape responses and central serotonergic parameters. Female rats were divided into four groups: non-pregnant control; non-pregnant chronic exposure; pregnant control; and pregnant chronic exposure. Male offspring were divided into four groups: chronic intrauterine sound exposure; acute sound exposure in adulthood; chronic intrauterine exposure with acute exposure in adulthood; and no exposure. Chronic sound exposure affected inhibitory avoidance and serotonergic parameters in female rats. For offspring, there was an interaction between chronic and acute sound exposure effects on inhibitory avoidance response but not on escape response. There were significant effects of chronic intrauterine exposure on serotonin turnover in the hippocampus and PFC of females. For offspring, the turnover was increased by chronic exposure only in PFC, and in amygdala it was increased by acute exposure. These results illuminate the potential of an early acoustic sound exposure for causing central serotonergic and emotional behavioral changes that can persist into later periods of life.
机译：在本研究中，我们评估了妊娠期长期暴露于22 kHz的声音对Wistar大鼠大坝哺乳期后及其雄性后代的中心血清素能和行为参数的影响。此外，我们还评估了与慢性子宫内暴露相关的急性22 kHz声音对成年后代情绪反应的影响。主要的假设是，在发育的早期阶段受到22 kHz的刺激会干扰大脑的血清素能参数，随后会干扰成年大鼠的防御反应。必然的问题是22 kHz的声音暴露是否会不同地影响抑制性回避和逃逸反应以及中心血清素能参数。将雌性大鼠分为四组：未怀孕对照组;未怀孕对照组;未怀孕对照组。非怀孕的慢性暴露;怀孕控制和怀孕的慢性暴露。雄性后代分为四组：慢性宫腔内声音暴露;成年期急性声暴露;慢性子宫内暴露，成年后急性暴露;而且没有暴露。慢性声音暴露会影响雌性大鼠的抑制回避和血清素能参数。对于后代来说，慢性和急性声音暴露对抑制回避反应的影响是相互作用的，但对逃避反应却没有影响。长期子宫内暴露对女性海马和PFC中5-羟色胺更新有显着影响。对于后代，仅通过PFC的长期暴露会增加营业额，而在杏仁核中，通过急性暴露会增加营业额。这些结果阐明了早期声暴露可能引起中枢血清素能和情绪行为改变的可能性，这种改变可以持续到以后的生活。

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