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首页> 外文期刊>Journal of Behavioral and Brain Science >Mechanism of Action of Low Dose Preparations from Coffea arabica, Gelsemium and Veratrum Based on in Vivo and in Vitro Neurophysiological Findings
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Mechanism of Action of Low Dose Preparations from Coffea arabica, Gelsemium and Veratrum Based on in Vivo and in Vitro Neurophysiological Findings

机译：基于体内和体外神经生理学发现的阿拉伯咖啡，香菜和藜芦小剂量制剂的作用机理

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Low dose remedies are widely administered in medicine. We used Tele-Stereo-EEG and the hippocampal slice preparation to measure physiological effects of orally given Coffea D6 (40 mg/kg), Gelsemium D4 (10 mg/kg) and Veratrum D6 (30 mg/kg) in rats. Adult rats were implanted with electrodes positioned stereotactically into four brain regions. Changes in field potentials were transmitted wirelessly. After frequency analysis data from 6 - 8 animals were averaged. For in vitro testing, preparations were superfused directly on hippocampal slices. Stimulation of Schaffer Collaterals by single stimuli (SS) or theta burst stimulation (TBS) resulted in stable population spike amplitudes. All three low dose preparations produced decreases of spectral power. Statistically significant changes were observed in delta, theta and alpha2 spectral power. In the hippocampal slice preparation Coffea facilitated signal transfer presumably by enhancing glutamate AMPA receptor transmission. Gelsemium showed a similar effect, but only after single shock stimulation. Opposite to this, attenuation of the electric pathway was recognized after theta burst stimulation due to AMPA receptor and glutamate metabotropic II receptor mediated transmission. Veratrum was able to attenuate glutamatergic due to receptor-mediated signalling sensitive to AMPA and NMDA. The results strongly speak in favour of the existence of biologically active molecules in these low dose preparations.
机译：在医学中广泛使用低剂量疗法。我们使用Tele-Stereo-EEG和海马切片制剂来测量在大鼠中口服Coffea D6（40 mg / kg），Gelsemium D4（10 mg / kg）和Veratrum D6（30 mg / kg）的生理作用。成年大鼠植入了立体定位在四个大脑区域中的电极。场电势的变化通过无线传输。频率分析后，取平均6-8只动物的数据。为了进行体外测试，将制剂直接融合在海马切片上。通过单一刺激（SS）或theta爆发刺激（TBS）刺激Schaffer侧支产生稳定的种群尖峰幅度。所有三种低剂量制剂均降低了光谱功率。在Δ，θ和α2光谱功率上观察到统计学上的显着变化。在海马切片中，咖啡可能通过增强谷氨酸AMPA受体的传递来促进信号传递。 Gelsemium表现出相似的效果，但仅在单次电击刺激之后。与此相反，由于AMPA受体和谷氨酸代谢型II受体介导的传递，在θ爆裂刺激后识别出电通路的衰减。由于受体介导的信号对AMPA和NMDA敏感，因此Veratrum能够减弱谷氨酸能。该结果强烈表明在这些低剂量制剂中存在生物活性分子。

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