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首页> 外文期刊>Journal of Behavioral and Brain Science >Blockade of Brain γ-Aminobutyric Acid a Receptors Antagonizes Hypnotic Action of Isoflurane in Rats―GABA Receptor and Isoflurane Induced Hypnosis
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Blockade of Brain γ-Aminobutyric Acid a Receptors Antagonizes Hypnotic Action of Isoflurane in Rats―GABA Receptor and Isoflurane Induced Hypnosis

机译：脑γ-氨基丁酸a受体的阻断拮抗异氟醚在大鼠中的催眠作用——GABA受体和异氟烷诱导的催眠作用

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摘要

Although in vitro studies have demonstrated that isoflurane potentiates the function of γ-aminobutyric acid A receptors (GABAARs), the in vivo data are controversial. To determine if GABAARs contribute to the loss-of righting reflex (LORR) induced by isoflurane, we studied the LORR in the absence and presence of gabazine, a competitive GABAAR antagonist, in Sprague-Dawley rats anesthetized with either isoflurane or ketamine. Administration of isoflurane and ketamine induced LORR in a dose-dependent manner. Gabazine significantly antagonized the effect of isoflurane and shifted the dose response curve to the right. In addition, gabazine prolonged the onset time of LORR induced by isoflurane. Ketamine induced LORR was not affected by gabazine. This indicates that centrally administered gabazine selectively blocks the effect of isoflurane, and the effect of gabazine is not due to a non-specific CNS excitatory action. These results suggest that the hypnotic effect of isoflurane is at least in part mediated by GABAARs.
机译：尽管体外研究表明异氟烷可增强γ-氨基丁酸A受体（GABAARs）的功能，但体内数据仍存在争议。为了确定GABAAR是否有助于异氟烷诱导的权利丧失反射（LORR），我们在有异氟醚或氯胺酮麻醉的Sprague-Dawley大鼠中，在不存在和存在竞争性GABAAR拮抗剂gabazine的情况下研究了LORR。异氟烷和氯胺酮的给药以剂量依赖性方式诱导LORR。加巴嗪显着拮抗异氟烷的作用并将剂量反应曲线向右移动。此外，加巴嗪会延长异氟烷诱导的LORR的发作时间。氯胺酮诱导的LORR不受gabazine的影响。这表明集中施用的gabazine选择性地阻断了异氟烷的作用，而gabazine的作用并非归因于非特异性的CNS兴奋作用。这些结果表明异氟烷的催眠作用至少部分由GABAAR介导。

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