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首页> 外文期刊>Journal of Behavioral and Brain Science >Depressive Cognitions May Affect Cingulate Neurochemistry in ADHD Patients
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Depressive Cognitions May Affect Cingulate Neurochemistry in ADHD Patients

机译：抑郁症认知可能会影响多动症患者的扣带神经化学

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Objectives: The anterior cingulate is thought to be essentially involved in impulsivity and affect regulation and in the pathogenesis of depression as well as of attention deficit/hyperactivity disorder. At the same time alterations in glutamatergic neurotransmission in the frontal forebrain have been found in imaging studies in Attention Deficit Hyperactivity Disorder (ADHD) and in depressive patients. Therefore we hypothesized that glutamate/glutamine (Glx) signals in the anterior cingulate cortex (ACC) of depressed ADHD patients might differ from that in non-depressed patients. Methods: Fourteen male adult patients with ADHD were included into the study. Chemical Shift Imaging of ACC was performed. Subgroups were defined based on scores on the Beck Depression Inventory (BDI) and ratios of metabolites were compared between groups. Additionally correlation analyses of BDI scores with metabolite ratios were calculated. Results: Significantly lower Glx signals and N-acetyl-aspartate (NAA) signals were found in the left anterior cingulate cortex of depressed ADHD patients. The Glx/Cr and NAAX/Cr ratios in the left ACC correlated significantly with BDI-scores. Conclusions: To our knowledge this is the first report about a relationship between depressive symptoms and metabolite disturbances in ACC of adult patients with ADHD. Our preliminary data produce first evidence for a putative link between neurochemical alterations in the ACC and depressive symptoms. They should be controlled for in further studies.
机译：目的：前扣带被认为主要参与冲动并影响调节，并参与抑郁症以及注意力不足/多动症的发病机理。同时，在注意力缺陷多动障碍（ADHD）和抑郁症患者的影像学研究中发现额叶前额谷氨酸能神经传递发生改变。因此，我们假设抑郁的ADHD患者的前扣带回皮质（ACC）中的谷氨酸/谷氨酰胺（Glx）信号可能与非抑郁患者的信号不同。方法：将14名男性多动症成人患者纳入研究。进行了ACC的化学位移成像。根据贝克抑郁量表（BDI）的得分定义亚组，并比较各组之间的代谢物比率。另外，还计算了BDI评分与代谢物比率的相关性分析。结果：在抑郁多动症患者的左前扣带皮层中发现了明显较低的Glx信号和N-乙酰基天冬氨酸（NAA）信号。左ACC中的Glx / Cr和NAAX / Cr比值与BDI得分显着相关。结论：据我们所知，这是关于成人ADHD患者抑郁症状与ACC代谢紊乱之间关系的第一个报道。我们的初步数据为ACC中的神经化学变化与抑郁症状之间的推测联系提供了初步证据。应该控制它们以进行进一步研究。

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