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首页> 外文期刊>Journal of Behavioral and Brain Science >Spatial Memory Deficits and Their Correlations with Clusters of Shrunken Neuronal Soma in the Cortices and Limbic System Following a “Mild’’ Mechanical Impact to the Dorsal Skull in Female Rats
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Spatial Memory Deficits and Their Correlations with Clusters of Shrunken Neuronal Soma in the Cortices and Limbic System Following a “Mild’’ Mechanical Impact to the Dorsal Skull in Female Rats

机译：在“轻度”机械撞击雌性大鼠背颅骨后，皮质和边缘系统的空间记忆缺陷及其与收缩的神经元体簇的相关性

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Background: Previous results showed that quantitative changes in behavioural accuracies by rats that sustained a “mild” closed head injury were moderately correlated with the total areas (numbers) of anomalous neuronal soma within regions below the impact. Method: Water maze behavioural measures within one day or two months after a single impact of mechanical force over the right dorsal skull, with or without stunning and with or without subsequent pregnancy, were measured and compared to proportions of anomalous neurons under the impact site. Results: The consequences of the impact accommodated about 20% of the variance in the rats’ scores for less proficient spatial learning and memory. There were significantly more anomalous cells within right hemisphere below the impact site that were correlated with poorer initial maze learning. Maternal experience reduced the numbers of anomalous cells in the right limbic area only. Conclusion: These results suggest weak mechanical impacts produce changes in histomorphology within some neurons that are still evident two months later and that the presence of these anomalous clusters, corresponding to less than 1% of the cross-sectional area and below the resolution of contemporary MRI in human cases, are strongly correlated with specific behavioural impairments.
机译：背景：先前的研究结果表明，遭受“轻度”闭合性颅脑损伤的大鼠的行为准确性的定量变化与影响下方区域内异常神经元体的总面积（数量）呈中等相关性。方法：测量机械力对右背颅骨的单次撞击后一天或两个月内水迷宫的行为量度，无论有无击晕，有无随后妊娠，均将其与撞击部位下异常神经元的比例进行比较。结果：由于缺乏足够的空间学习和记忆能力，撞击的后果适应了大鼠分数的20％左右的差异。撞击部位下方右半球内异常细胞的数量明显增加，这与较差的初始迷宫学习有关。产妇的经验仅减少了右边缘区的异常细胞数量。结论：这些结果表明，弱的机械冲击会在一些神经元内产生组织形态学变化，这种变化在两个月后仍很明显，并且这些异常簇的存在，相当于横截面积的不到1％，并且低于当代MRI的分辨率在人类病例中，与特定的行为障碍密切相关。

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