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首页> 外文期刊>Neuroscience Research: The Official Journal of the Japan Neuroscience Society >Spatial working memory learning in young male and female rats: involvement of different limbic system regions revealed by cytochrome oxidase activity.
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Spatial working memory learning in young male and female rats: involvement of different limbic system regions revealed by cytochrome oxidase activity.

机译：年轻的雄性和雌性大鼠的空间工作记忆学习：细胞色素氧化酶活性揭示了不同边缘系统区域的参与。

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摘要

Sex differences have been found in the spatial memory which involve several regions of the limbic system. The Morris water maze (MWM) is one of the most widely used tasks in behavioral neuroscience to explore spatial and episodic memory in rats. We evaluated the oxidative metabolic activity of the prefrontal cortex, dorsal hippocampus, anterior thalamic nuclei and mammillary region following the acquisition of a spatial working memory (WM) task in young rats (30 days) of both sexes using quantitative histochemistry of the cytochrome oxidase (COx). The rats were trained until they achieved the learning criteria in the MWM using a hidden escape platform with different daily locations, and two control groups were added to evaluate the oxidative metabolism not specific to the learning task. We found a delay in the acquisition of the WM in females. A significant decrease in COx activity was found in the prefrontal cortex in both sexes. Also, changes were found in the dentate gyrus and lateral mammillary nucleus in males, whereas females showed changes in the anterodorsal thalamus and CA3. These results suggest a sex difference in the contribution of brain limbic structures to the WM process during postnatal development.
机译：在空间记忆中发现了性别差异，涉及边缘系统的多个区域。莫里斯水迷宫（MWM）是行为神经科学中探索大鼠空间记忆和情节记忆的最广泛使用的任务之一。我们使用细胞色素氧化酶的定量组织化学方法（30天）在获得了雌雄大鼠（30天）的空间工作记忆（WM）任务后，评估了前额叶皮层，背侧海马，丘脑前核和乳头区域的氧化代谢活性。 COx）。对大鼠进行训练，直到他们使用隐藏的逃生平台（每天位置不同）在MWM中达到学习标准为止，并添加了两个对照组来评估并非专门针对学习任务的氧化代谢。我们发现女性购买WM的时间有所延迟。在男女的前额叶皮层中发现了COx活性的显着降低。另外，在雄性的齿状回和乳突外侧核中发现了变化，而雌性的前丘脑和CA3发生了变化。这些结果表明，在产后发育过程中脑边缘结构对WM过程的贡献存在性别差异。

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