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首页> 外文期刊>Journal of Allergy >Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis
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Meta-Analysis of the Efficacy of Ectoine Nasal Spray in Patients with Allergic Rhinoconjunctivitis

机译：鼻鼻窦结膜炎过敏性鼻结膜炎疗效的Meta分析

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Objectives. The meta-analysis aims to investigate the efficacy of ectoine nasal spray and eye drops in the treatment of allergic rhinitis and rhinoconjunctivitis symptoms. Design and Methods. This meta-analysis is based on yet unpublished data of four studies. Both nasal and eye symptoms were documented in patient diary cards. All scales were transformed into a 4-point scale 0 = no, 1 = mild, 2 = moderate, and 3 = severe symptoms. Each symptom was analysed individually in a meta-analysis of the area under the curve values as well as in a meta-analysis of pre- and posttreatment comparison. Results. After seven days of treatment with ectoine nasal spray both nasal and ocular symptoms decreased significantly. A strong reduction of symptom severity was shown for the parameters rhinorrhoea (31.76% reduction) and nasal obstruction (29.94% reduction). Furthermore, the meta-analyses of individual symptoms to investigate the strength of effect after seven days of medication intake showed significant improvement for nasal obstruction, rhinorrhoea, nasal itching, sneezing, itching of eyes, and redness of eyes. The improvement of the symptom nasal obstruction was associated with a strong effect 0.53 (±0.26). Conclusions. The ectoine nasal spray and eye drops seem to be equally effective as guideline-recommended medication in the treatment of rhinoconjunctivitis symptoms.
机译：目标。荟萃分析旨在研究鼻腔喷剂和滴鼻剂在过敏性鼻炎和鼻结膜炎症状治疗中的功效。设计和方法。这项荟萃分析基于尚未发表的四项研究数据。病人的日记卡中记录了鼻和眼的症状。将所有量表转换为4点量表，0 =否，1 =轻度，2 =中度和3 =严重症状。通过对曲线值下方区域的荟萃分析以及治疗前后比较的荟萃分析，分别对每种症状进行了分析。结果。用外用鼻腔喷雾剂治疗7天后，鼻和眼症状均明显减轻。对于参数性鼻出血（减少31.76％）和鼻塞（减少29.94％），症状严重程度明显降低。此外，对个体症状进行荟萃分析以研究服药7天后的效果强度，显示鼻塞，鼻涕，鼻痒，打喷嚏，眼睛瘙痒和眼睛发红明显改善。症状性鼻塞的改善与强效0.53（±0.26）相关。结论。外用鼻喷雾剂和滴眼剂似乎在治疗鼻结膜炎症状方面与指南推荐的药物同样有效。

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