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首页> 外文期刊>Journal of Biomarkers >Tissue Reactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Tumors of Neuroectodermal, Mesodermal, and Epithelial Origin
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Tissue Reactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Tumors of Neuroectodermal, Mesodermal, and Epithelial Origin

机译：在神经外胚层，中胚层和上皮来源的肿瘤中针对N-乙二醇基GM3神经节苷脂提高14F7单抗的组织反应性

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摘要

The expression of N-glycolylneuraminic acid forming the structure of gangliosides and/or other glycoconjugates (Hanganutziu-Deicher antigen) in human has been considered as a tumor-associated antigen. Specifically, some reports of 14F7 Mab (a highly specific Mab raised against N-glycolyl GM3 ganglioside) reactivity in human tumors have been recently published. Nevertheless, tumors of epithelial origin have been mostly evaluated. The goal of the present paper was to evaluate the immunohistochemical recognition of 14F7 Mab in different human tumors of neuroectodermal, mesodermal, and epithelial origins using an immunoperoxidase staining method. Samples of fetal, normal, and reactive astrocytosis of the brain were also included in the study. In general, nontumoral tissues, as well as, low-grade brain tumors showed no or a limited immunoreaction with 14F7 Mab. Nevertheless, high-grade astrocytomas (III-IV) and neuroblastomas, as well as, sarcomas and thyroid carcinomas were mostly reactive with 14F7. No reaction was evidenced in medulloblastomas and ependymoblastomas. Our data suggest that the expression of N-glycolyl GM3 ganglioside could be related to the aggressive behavior of malignant cells, without depending on the tumor origin. Our data could also support the possible use of N-glycolyl GM3 as a target for both active and passive immunotherapies of malignancies expressing this molecule.
机译：形成神经节苷脂和/或其他糖缀合物（Hanganutziu-Deicher抗原）的结构的N-羟甲基神经氨酸的表达被认为是与肿瘤相关的抗原。具体而言，最近已经发表了一些关于人肿瘤中14F7 Mab（针对N-羟甲基GM3神经节苷脂的高度特异性Mab）反应性的报道。尽管如此，大多数上皮来源的肿瘤已得到评估。本文的目的是使用免疫过氧化物酶染色方法评估14F7 Mab在神经外胚层，中胚层和上皮起源的不同人类肿瘤中的免疫组织化学识别。胎儿，正常和反应性星形细胞增多症的样本也包括在研究中。通常，非肿瘤组织以及低度脑肿瘤对14F7 Mab均未显示免疫反应或免疫反应有限。尽管如此，高级星形细胞瘤（III-IV）和神经母细胞瘤以及肉瘤和甲状腺癌大多与14F7反应。在髓母细胞瘤和上皮细胞母细胞瘤中未发现反应。我们的数据表明，N-甘氨酰GM3神经节苷脂的表达可能与恶性细胞的侵袭行为有关，而与肿瘤的起源无关。我们的数据还可能支持使用N-羟甲基GM3作为表达该分子的恶性肿瘤主动和被动免疫治疗的靶标。

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