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首页> 外文期刊>Journal of Biomarkers >Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes)
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Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes)

机译：审查的数据分析揭示了年龄和丙型肝炎感染对健康成年黑猩猩（盘尾猿）中C反应蛋白水平的影响

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C-reactive protein, a conserved acute-phase protein synthesized in the liver and involved in inflammation, infection, and tissue damage, is an informative biomarker for human cardiovascular disease. Out of 258 captive adult common chimpanzees (Pan troglodytes) assayed for CRP, 27.9% of the data were below the quantitation limit. Data were analyzed by the Kaplan-Meier method and results compared to other methods for handling censored data (including deletion, replacement, and imputation). Kaplan-Meier results demonstrated a modest age effect and a strong effect of HCV infection in reducing CRP but did not allow inference of reference intervals. Results of other methods varied considerably. Substitution schemes differed widely in statistical significance, with estimated group means biased by the size of the substitution constant, while inference of unbiased reference intervals was impossible. Single imputation gave reasonable statistical inferences but unreliable reference intervals. Multiple imputation gave reliable results, for both statistical inference and reference intervals, and was comparable to the Kaplan-Meier standard. Other methods should be avoided. CRP did not predict cardiovascular disease, but CRP levels were reduced by 50% in animals with hepatitis C infection and showed inverse relationships with 2 liver function enzymes. Results suggested that hsCRP can be an informative biomarker of chronic hepatic dysfunction.
机译：C反应蛋白是在肝脏中合成的一种保守的急性期蛋白，与炎症，感染和组织损伤有关，是人类心血管疾病的有益生物标志物。在测定的CRP的258只成年普通黑猩猩（Pan穴居人）中，有27.9％的数据低于定量限。通过Kaplan-Meier方法分析数据，并将结果与​​其他处理审查数据的方法（包括删除，替换和归因）进行比较。 Kaplan-Meier结果表明适度的年龄效应和HCV感染在降低CRP方面具有很强的作用，但无法推断参考区间。其他方法的结果差异很大。替代方案的统计意义差异很大，估计组均数受替代常数大小的影响，而无偏参考区间的推断是不可能的。单一估算得出合理的统计推断，但参考区间不可靠。对于统计推论和参考区间，多重插补给出了可靠的结果，与Kaplan-Meier标准相当。应避免其他方法。 CRP不能预测心血管疾病，但是C型肝炎感染动物的CRP水平降低了50％，并且与2种肝功能酶呈负相关。结果表明，hsCRP可以作为慢性肝功能不全的信息性生物标志物。

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