...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Blood Medicine >Emerging antithrombotic agents for thromboprophylaxis, clinical potential and patient considerations
【24h】

Emerging antithrombotic agents for thromboprophylaxis, clinical potential and patient considerations

机译：新兴的抗血栓药物用于血栓预防，临床潜力和患者考虑

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract: Patients undergoing major orthopedic surgery, total hip arthroplasty (THA) and total knee arthroplasty (TKA) are at high risk of venous thromboembolism, manifesting as deep vein thrombosis or pulmonary embolism. The recommended pharmacologic treatment options for thromboprophylaxis after major orthopedic surgery include the vitamin K -antagonists (VKAs eg, warfarin), low molecular weight heparins (LMWHs; eg, enoxaparin) and the synthetic pentasaccharide fondaparinux. Most clinics use some kind of thromboprophylaxis routinely. However, due to the frequent need for coagulation monitoring (VKAs) and subcutaneous -injections (LMWHs and fondaparinux) barriers exist to prescribing prophylaxis after discharge from hospital. Targeting specific components of the coagulation cascade has yielded several new antithrombotic agents for use as thromboprophylaxis after THA or TKA. Two of these, dabigatran etexilate and rivaroxaban, have already reached the markets in the European Union member states and Canada. Both are administered by the oral route, once-daily fixed dose and without the need to monitor the anticoagulant effect. Whether these new drugs facilitate guideline adherence, particularly in the outpatient settings and thereby improve the overall clinical outcomes remains to be shown.
机译：摘要：接受大骨外科手术，全髋关节置换术（THA）和全膝关节置换术（TKA）的患者存在静脉血栓栓塞的高风险，表现为深静脉血栓形成或肺栓塞。骨科手术后预防血栓的推荐药物治疗选择包括维生素K拮抗剂（VKA，例如华法林），低分子量肝素（LMWH;例如依诺肝素）和合成的五糖磺达肝素。大多数诊所常规使用某种形式的血栓预防措施。但是，由于对凝血监测（VKA）和皮下注射（LMWH和fondaparinux）的经常性需求，在出院后存在用于预防的障碍。针对凝血级联反应的特定成分，已经产生了几种新的抗血栓形成剂，可用于THA或TKA后的血栓预防。其中的两种，达比加群酯和利伐沙班已经进入了欧盟成员国和加拿大市场。两者均通过口服途径给药，每天一次固定剂量，无需监测抗凝作用。这些新药是否能促进指南的依从性，特别是在门诊患者中是否如此，从而改善总体临床结果尚待证实。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号