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首页> 外文期刊>Journal of Advances in Biomedical Studies >EFFECT OF CORDIA MILLENII EXTRACT ON REPRODUCTIVE HORMONE IN CISPLATIN INDUCED INFERTILITY IN FEMALE ALBINO RATS
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EFFECT OF CORDIA MILLENII EXTRACT ON REPRODUCTIVE HORMONE IN CISPLATIN INDUCED INFERTILITY IN FEMALE ALBINO RATS

机译：MIL子提取物对CISPLATIN诱导的女性白化大鼠不育症中生殖激素的影响

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Cordia millenii?is a plant that belongs to the family Boraginaceae family, commonly known as African Cordia. In Nigeria, its Igbo name is okwe, omo in Yoruba and waawankurmii in Hausa. Various parts of?Cordia millenii?has been used as a restorative medicine for treatment of fever, general body weakness and stomach- ache. The present study was carried out to determine the effect of graded doses of ethanol leaf extract of?Cordia millenii?on fertility hormone in cisplatin induced infertility of female albino rats. Twenty four (24) healthy female rats weighing between 95 kg – 140 kg were divided into five groups. Group 1 served as the control, the animals in group 2 received an intraperitoneal dose of cisplatin (5mgkg-1 body weight). Animals in groups three and four received combination of oral dose of?Cordia millenii?ethanol extract 100 mgkg-1, 200 mg kg-1 body weight and cisplatin in 5 mg kg-1 , while animals in group five received an oral dose of?Cordia millenii?extract only (100 mgkg-1) for 14days. At the end of the study two rats were randomly selected from the cisplatin group for the mating study and blood samples were taken from the other rats in various groups for hormonal analysis. The result from the mating study revealed that cisplatin caused an irreversible infertility in the rats as no conception was achieved after 8 weeks. The estrogen level reduced in the cisplatin, low and high dose of?Cordia millenii?plus cisplatin and?Cordia millenii?extract only groups. Results from this study have shown the antifertility effect of?Cordia millenii?ethanol extract. Therefore, awareness should be created to avoid using?Cordia millenii?leaves in the treatment of infertility as currently; traditional health practitioners believe that this plant enhances fertility.
机译：Cordia millenii？是一种属于Boraginaceae科的植物，通常被称为非洲Cordia。在尼日利亚，它的伊博语名称是okwe，约鲁巴语是omo，豪萨语是waawankurmii。千Cor（Cordia millenii）的各个部位已被用作治疗发烧，全身无力和胃痛的修复药物。本研究旨在确定分级剂量的“ Cordia millenii”乙醇叶提取物对顺铂诱发的女性白化病大鼠不育激素的影响。将二十四（24）只体重在95公斤至140公斤之间的健康雌性大鼠分为五组。第1组作为对照，第2组的动物接受腹膜内剂量的顺铂（5mgkg-1体重）。第三和第四组的动物接受口服剂量的百日草乙醇提取物100 mgkg-1、200 mg kg-1体重和5 mg kg-1的顺铂的组合，而第五组的动物接受口服剂量的？只用Cordia millenii？（100 mgkg-1）提取14天。在研究结束时，从顺铂组中随机选择两只大鼠进行交配研究，并从各组中的其他大鼠中采集血样进行激素分析。交配研究的结果显示，顺铂在大鼠中引起不可逆的不育，因为8周后未达到任何意向。顺铂，低剂量和高剂量的“ Cordia millenii”加顺铂和“ Cordia millenii”仅提取组的雌激素水平降低。这项研究的结果显示了千层Cordia millenii乙醇提取物的抗生育作用。因此，应该提高意识，避免像现在这样使用叶Cordia millenii？治疗不孕症。传统的卫生从业人员认为，这种植物可以增强生育能力。

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