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首页> 外文期刊>Journal of Advances in Medical and Pharmaceutical Sciences >Effects of Citrus Limon Juice on Serum Bilirubin, High Density Lipoprotein and Low Density Lipoprotein in Adult Male Wistar Rats under Variable Models of Stress
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Effects of Citrus Limon Juice on Serum Bilirubin, High Density Lipoprotein and Low Density Lipoprotein in Adult Male Wistar Rats under Variable Models of Stress

机译：不同压力模型下柑橘柠檬汁对成年雄性Wistar大鼠血清胆红素，高密度脂蛋白和低密度脂蛋白的影响

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Introduction: There has been sufficient awareness on atherosclerosis but this has not reduced the number of people with it. Atherosclerosis is promoted by low density lipoprotein (LDL) without sufficient removal of fats and cholesterol by high density lipoprotein (HDL). Stress is linked with hyperlipidemia, lowering HDL and increasing LDL levels. Citrus Limon is known for its rich minerals and flavonoid content which have been employed widely. This study is aimed at assessing the hypolipidemic effects of citrus Limon on Bilirubin, HDL and LDL levels. Place and Duration of Study: Department of physiology, Delta State University Abraka. Methods: Experimental animals were divided into six groups. Group I were control group rats fed with feed ad libitum , Group II were negative control rats (stressed but not treated), Group III-V were rats stressed and treated with 0.5 ml/kg, 1 ml/kg and 2 ml/kg of Citrus Limon juice respectively, Group VI treated with 0.2 ml/kg of Vitamin C. The animals were sacrificed by cervical dislocation after 14 days and blood samples were collected for biochemical analysis. Data were analyzed using SPPS and expressed as Means±Standard Error of Mean with significance at p<0.05. Results: Results showed that stress significantly (p<0.05) increased bilirubin and LDL and reduced HDL levels. Result also showed that Citrus limon administration significantly reduced serum bilirubin and LDL but increased HDL levels in experimental animals after 14 days. Conclusion: This study concludes that stress raises serum bilirubin and LDL levels and reduces HDL levels thus a major risk factor towards development of atherosclerosis. Administration of Citrus limon juice however reduces serum bilirubin and LDL while increasing HDL levels.
机译：简介：人们对动脉粥样硬化有了足够的认识，但这并没有减少患有动脉粥样硬化的人数。低密度脂蛋白（LDL）促进动脉粥样硬化，而高密度脂蛋白（HDL）不能充分去除脂肪和胆固醇。压力与高脂血症，降低HDL和增加LDL水平有关。柑橘柠檬酒因其丰富的矿物质和类黄酮含量而闻名，已被广泛采用。这项研究旨在评估柑橘柠檬对胆红素，HDL和LDL水平的降血脂作用。学习地点和持续时间：三角州立大学阿布拉卡分校生理系。方法：将实验动物分为六组。第一组是随意喂食的对照组大鼠，第二组是阴性对照大鼠（应激但未治疗），第三至第五组是应激大鼠，分别用0.5 ml / kg，1 ml / kg和2 ml / kg的生理盐水处理。 VI组分别用0.2 ml / kg维生素C处理的柑橘柠檬汁。在14天后通过颈脱位法处死动物，并收集血样进行生化分析。使用SPPS分析数据，并表示为平均值±平均值的标准误差，在p <0.05时具有显着性。结果：结果表明，压力显着（p <0.05）增加了胆红素和LDL，降低了HDL水平。结果还表明，柑桔柠檬酸酯给药可显着降低14天后实验动物的血清胆红素和LDL，但增加HDL水平。结论：本研究得出结论，压力会升高血清胆红素和低密度脂蛋白水平并降低高密度脂蛋白水平，因此是导致动脉粥样硬化发展的主要危险因素。然而，柑橘柠檬汁的使用减少了血清胆红素和低密度脂蛋白，同时增加了高密度脂蛋白水平。

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