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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Anti-sarcopenic effects of diamino-diphenyl sulfone observed in elderly female leprosy survivors: a cross-sectional study
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Anti-sarcopenic effects of diamino-diphenyl sulfone observed in elderly female leprosy survivors: a cross-sectional study

机译：在老年女性麻风病幸存者中观察到的二氨基二苯砜的抗肌肉收缩作用：一项横断面研究

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Abstract Background It has been reported that 4,4?￠???2-diamino-diphenyl sulfone (DDS), the longtime treatment of choice for leprosy, prolongs the lifespan and increases mobility in animal models by reducing the levels of reactive oxygen species and inhibiting muscle pyruvate kinase activity. This study aimed to investigate whether sarcopenic status in leprosy survivors was influenced by recent history of DDS medication. Methods Forty-one elderly female leprosy survivors were recruited. The DDS group was defined as survivors who had been taking the drug for the past year or more. Body composition measured by dual energy X-ray absorptiometry, limb muscle strength, short physical performance battery, and International Physical Activity Questionnaire in Korean were compared. Results The DDS group tended to have higher skeletal muscle mass index (24.4 ???± 2.7 vs. 22.6 ???± 2.2%, P = 0.066) and regional skeletal muscle mass index in non-dominant leg (8.9 ???± 1.0 vs. 7.9 ???± 0.9%, P = 0.018) than those of the control group although they had significantly worse leprosy disability than the control group ( P = 0.027). The DDS group had greater strength than the control group in non-dominant shoulder abductor, elbow flexor, hip flexor, and knee extensor ( P = 0.005, P = 0.029, P = 0.021, and P = 0.002, respectively). Weekly walking amount was significantly longer ( P = 0.020) in the DDS group than the control group. The total lifetime DDS exposure significantly correlated with skeletal muscle mass of the lower extremity in non-dominant leg ( r = 0.379, P = 0.015). Conclusions DDS-taking leprosy survivors had larger skeletal muscle mass and greater muscle strength over non-taking survivors. There was a dose?￠????response relationship between total lifetime DDS exposure and skeletal muscle mass of lower extremity. These findings might suggest potential anti-sarcopenic effects of DDS.
机译：抽象背景据报道，长期选择治疗麻风病的4,4 ￠ 2-二氨基二苯砜（DDS）可通过降低活性氧的含量来延长动物模型的寿命并增加其活动性。并抑制肌肉丙酮酸激酶的活性。这项研究旨在调查麻风幸存者的肌肉减少状态是否受到DDS药物近期史的影响。方法招募41名老年女性麻风病幸存者。 DDS组被定义为过去一年或更长时间服用该药物的幸存者。比较了通过双能X射线吸收法测量的身体成分，肢体肌肉力量，身体机能不足和韩国的国际体育活动问卷。结果DDS组倾向于具有较高的骨骼肌质量指数（24.4±2.7 vs. 22.6±2.2％，P = 0.066），并且在非优势腿中具有较高的局部骨骼肌质量指数（8.9±0.2）。尽管它们的麻风病致残率比对照组明显差（P = 0.027），但与对照组相比，分别为1.0 vs. 7.9±0.9％，P = 0.018）。在非主要的肩外展肌，肘屈肌，髋屈肌和膝关节伸肌方面，DDS组的强度比对照组高（分别为P = 0.005，P = 0.029，P = 0.021和P = 0.002）。 DDS组的每周步行量显着长于对照组（P = 0.020）。终生DDS暴露总量与非优势腿下肢骨骼肌质量显着相关（r = 0.379，P = 0.015）。结论服用DDS的麻风病幸存者比不服用DDS的麻风幸存者具有更大的骨骼肌质量和更大的肌力。终生总DDS暴露与下肢骨骼肌质量之间存在剂量-反应关系。这些发现可能表明DDS具有潜在的抗肌肉紧张作用。

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