Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Anita E. M. Kneppers; Eulampio José Silva Neto; Annemie M. W. J. Schols; Rebeca Danielly da Fonseca Farias; Severino Aires Araujo Neto; José D. Vílchez; Bartolomeu Fragoso Cavalcanti Neto; Ramon C. J. Langen; Josep M. Argilés; Karin J. C. Sanders; Cláudia Martina Araújo Duarte; Ricardo Rueda; María D. Girón; José M. López-Pedrosa; Rafael Salto; Manuel Manzano; Nefertiti Campos; Coby van de Bool; Carlos Fernando de Mello Júnior; Natalia Sevillano; Gustavo Ramalho Pessoa Negromonte; Henrique Almeida Franca

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Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

机译：慢性阻塞性肺疾病的恶病质：新见解和治疗观点

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Abstract Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD-induced cachexia.

机译：摘要恶病质和肌肉消瘦是公认的慢性阻塞性肺疾病（COPD）的常见且部分可逆的特征，对疾病的进展和预后产生不利影响。这主张在患者护理中整合体重和维持肌肉。在这篇综述中，最近的见解提出了COPD肌肉消瘦的诊断，肌肉消瘦的病理生理学以及作为恶病质驱动因素参与了能量平衡紊乱的推定机制。我们讨论了这些新见解对COPD诱导的恶病质的优化和个性化管理的治疗意义。

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《Journal of Cachexia, Sarcopenia and Muscle》 |2015年第1期|共页
作者
Anita E. M. Kneppers; Eulampio José Silva Neto; Annemie M. W. J. Schols; Rebeca Danielly da Fonseca Farias; Severino Aires Araujo Neto; José D. Vílchez; Bartolomeu Fragoso Cavalcanti Neto; Ramon C. J. Langen; Josep M. Argilés; Karin J. C. Sanders; Cláudia Martina Araújo Duarte; Ricardo Rueda; María D. Girón; José M. López-Pedrosa; Rafael Salto; Manuel Manzano; Nefertiti Campos; Coby van de Bool; Carlos Fernando de Mello Júnior; Natalia Sevillano; Gustavo Ramalho Pessoa Negromonte; Henrique Almeida Franca;
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1. Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective [J] . Anita E. M. Kneppers, Eulampio José Silva Neto, Annemie M. W. J. Schols, Journal of Cachexia, Sarcopenia and Muscle . 2015,第1期

机译：慢性阻塞性肺疾病的恶病质：新见解和治疗观点
2. Correlation of chronic obstructive pulmonary disease assessment test and clinical chronic obstructive pulmonary disease questionnaire score with BODE index in patients of stable chronic obstructive pulmonary disease [J] . Shashank Singh, Mradul Kumar Daga, HS Hira, Lung India . 2018,第6期

机译：稳定型慢性阻塞性肺疾病患者的慢性阻塞性肺疾病评估测试和临床慢性阻塞性肺疾病问卷评分与BODE指数的相关性
3. Examining the Effects of Age on Health Outcomes of Chronic Obstructive Pulmonary Disease: Results From the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts [J] . Amit D. Parulekar, Carlos Martinez, Chu-Lin Tsai, Journal of the American Medical Directors Association . 2017,第12期

机译：检查年龄对慢性阻塞性肺病的健康结果的影响：慢性阻塞性肺病研究和慢性阻塞性肺病的遗传流行病学的结果纵向识别预测替代终点队列
4. CHRONIOUS: An open, ubiquitous and adaptive chronic disease management platform for Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Disease (CKD) and renal insufficiency [C] . Rosso R., Munaro G., Salvetti O., 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：慢性病：针对慢性阻塞性肺疾病（COPD），慢性肾脏病（CKD）和肾功能不全的开放，无处不在的适应性慢性疾病管理平台
5. Providing ethical care: Cardiopulmonary Resuscitation (CPR) for Chronic Obstructive Pulmonary Disease (COPD) Exacerbations in Patients with End Stage Lung Disease (ESLD). [D] . Young, Jeanne. 2010

机译：提供伦理护理：心肺复苏术（CPR）用于终末期肺病（ESLD）患者的慢性阻塞性肺疾病（COPD）加重。
6. Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective [O] . Karin J. C. Sanders, †, Anita E. M. Kneppers, 2016

机译：慢性阻塞性肺疾病的恶病质：新见解和治疗视角
7. Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective [O] . Sanders, Karin J. C., Kneppers, Anita E. M., van de Bool, Coby, 2016

机译：慢性阻塞性肺疾病的恶病质：新见解和治疗视角

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

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