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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Sarcopenia, obesity and sarcopenic obesity: effects on liver function and volume in patients scheduled for major liver resection
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Sarcopenia, obesity and sarcopenic obesity: effects on liver function and volume in patients scheduled for major liver resection

机译：肌肉减少症，肥胖症和肌肉减少症肥胖症：对计划进行大范围肝切除的患者的肝功能和容量的影响

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AbstractBackgroundSarcopenia, obesity and sarcopenic obesity have been linked to impaired outcome after liver surgery. Preoperative liver function of sarcopenic, obese and sarcopenic-obese patients might be reduced, possibly leading to more post-operative morbidity. The aim of this study was to explore whether liver function and volume were influenced by body composition in patients undergoing liver resection.MethodsIn 2011 and 2012, all consecutive patients undergoing the methacetin breath liver function test were included. Liver volumetry and muscle mass analysis were performed using preoperative CT scans and Osirix® software. Muscle mass and body-fat% were calculated. Predefined cut-off values for sarcopenia and the top two body-fat% quintiles were used to identify sarcopenia and obesity, respectively. Histologic assessment of the resected liver gave insight in background liver disease.ResultsA total number of 80 patients were included. Liver function and volume were comparable in sarcopenic(-obese) and non-sarcopenic(-obese) patients. Obese patients showed significantly reduced liver function [295 (95–508) vs. 358 (96–684) µg/kg/h, P = 0.018] and a trend towards larger liver size [1694 (1116–2685) vs. 1533 (869–2852) mL, P = 0.079] compared with non-obese patients. Weight (r = −0.40), body surface area (r = −0.32), estimated body-fat% (r = −0.43) and body mass index (r = −0.47) showed a weak but significant negative (all P  0.05) correlation with liver function. Moreover, body-fat% was identified as an independent factor negatively affecting the liver function.ConclusionSarcopenia and sarcopenic obesity did not seem to influence liver size and function negatively. However, obese patients had larger, although less functional, livers, indicating dissociation of liver function and volume in these patients.
机译：摘要背景肌肉减少症，肥胖和肌肉减少症与肝脏手术后的预后受损有关。少肌，肥胖和少肌肥胖患者的术前肝功能可能会降低，可能导致更多的术后发病率。这项研究的目的是探讨接受肝切除术的患者肝功能是否受身体组成的影响。方法在2011年和2012年，所有接受美沙西汀呼气性肝功能检查的连续患者均包括在内。使用术前CT扫描和Osirix ®软件进行肝脏容量测定和肌肉质量分析。计算肌肉质量和体脂％。肌肉减少症和身体脂肪百分比最高的两个五分位数的预定义临界值分别用于识别肌肉减少症和肥胖症。对切​​除的肝脏进行组织学评估可了解背景肝脏疾病。结果共纳入80例患者。少肌（肥胖）和非少肌（肥胖）患者的肝功能和容量相当。肥胖患者的肝功能显着降低[295（95–508）vs. 358（96–684）µg / kg / h，P = 0.018]，并且肝脏体积更大[1694（1116–2685）与1533（ 869-2852）mL，P = 0.079]。体重（r = −0.40），体表面积（r = −0.32），估计体脂％（r = −0.43）和体重指数（r = −0.47）显示为弱但显着的负值（所有P <0.05） ）与肝功能的相关性。此外，体脂％被认为是负面影响肝功能的独立因素。结论少肌症和少肌症肥胖似乎对肝脏的大小和功能没有负面影响。但是，肥胖患者的肝脏虽然较大，但功能较弱，表明这些患者的肝功能和容量均已分离。

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