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首页> 外文期刊>Journal of Addiction >Evaluation of Immunomodulatory and Hematologic Cell Outcome in Heroin/Opioid Addicts
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Evaluation of Immunomodulatory and Hematologic Cell Outcome in Heroin/Opioid Addicts

机译：海洛因/阿片类药物成瘾者的免疫调节和血液细胞结果评估

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The long-term use of opioids leads alternations in both innate-adaptive immune systems and other diagnostic hematologic cells. The purpose of this study is to evaluate the alterations of these parameters in patients with heroin/opioid addictions. Adults, meeting the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria of the American Psychiatric Association regarding opioid use disorder (Heroin Group or HG, n = 51) and healthy controls (Control Group or CG, n = 50), were included in the study. All hematological parameters, inflammation indexes (neutrophil-lymphocyte ratio and platelet-lymphocyte ratio), and iron panel were compared with the controls. Mean corpuscular volume, red blood cell distribution width, mean corpuscular hemoglobin content, unsaturated iron-binding capacity, and total iron-binding capacity were significantly higher in HG compared to CG, while red blood cell count, hemoglobin, hematocrit, and serum iron levels were significantly lower. Additionally, platelet and platelet distribution width were significantly high while mean platelet volume was low in HG. Regarding the parameters related to immunity, white blood cell, neutrophil count, and neutrophil percentage were significantly high while lymphocyte percentage and basophils count were significantly low. Besides, inflammatory indexes were significantly higher in HG compared to CG. Intravenous administration of heroin resulted in lower levels of hemoglobin, hematocrit, and mean corpuscular volume than inhalation and intranasal administration. Our data demonstrated that chronic use of opioids is related to all of the hematologic series. The chronic use of opioid alters the immunologic balance in favor of innate immunity cells and changes the hematometric/morphometric characteristics of erythrocytes. What is more, the route of heroin administration should be taken into consideration as well. This study may lead to a better understanding of the hematological effects of heroin/opioid use in patients with relevant addictions.
机译：长期使用阿片类药物会导致先天适应性免疫系统和其他诊断性血液系统细胞发生交替。这项研究的目的是评估海洛因/阿片类药物成瘾患者中这些参数的变化。成人，符合美国精神病学协会关于阿片类药物使用障碍（海洛因组或HG，n = 51）和健康对照组（对照组或CG，n的第五版《精神疾病诊断和统计手册》（DSM-5）标准） = 50），包括在研究中。将所有血液学参数，炎症指标（中性粒细胞-淋巴细胞比和血小板-淋巴细胞比）以及铁含量与对照组进行比较。与CG相比，HG的平均红细胞体积，红细胞分布宽度，平均红细胞血红蛋白含量，不饱和铁结合能力和总铁结合能力显着高于CG，而红细胞计数，血红蛋白，血细胞比容和血清铁水平明显降低。另外，HG中血小板和血小板分布宽度显着高，而平均血小板体积低。关于与免疫相关的参数，白细胞，中性粒细胞计数和中性粒细胞百分比显着较高，而淋巴细胞百分比和嗜碱性粒细胞计数则显着较低。此外，HG的炎症指数明显高于CG。与吸入和鼻内给药相比，静脉内注射海洛因可导致较低的血红蛋白，血细胞比容和平均红细胞体积。我们的数据表明，阿片类药物的长期使用与所有血液学系列有关。阿片类药物的长期使用改变了免疫平衡，有利于先天免疫细胞，并改变了红细胞的血液学/形态学特征。此外，还应考虑海洛因的给药途径。这项研究可能会更好地了解海洛因/阿片类药物对相关成瘾患者的血液学影响。

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