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首页> 外文期刊>Journal of Addiction >Health Related Quality of Life in Individuals Transferred from a Needle Exchange Program and Starting Opioid Agonist Treatment
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Health Related Quality of Life in Individuals Transferred from a Needle Exchange Program and Starting Opioid Agonist Treatment

机译：从针头交换计划转移并开始阿片类激动剂治疗的个人的健康相关生活质量

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Background. Opioid agonist treatment (OAT), for the treatment of heroin dependence, has been reported to improve overall health and lower mortality. Drug use and retention in treatment have often been used as measures of treatment success. More recently, however, researchers have suggested that measurements of quality of life should be an outcome in substance use treatment evaluations. In a recent randomized controlled trial we demonstrated high rates of successful rapid referral from a needle exchange program (NEP) to OAT. The aim of this study was to see whether an improvement in health related quality of life (HRQoL) could be seen at 3-month follow-up after starting OAT and whether it was associated with any baseline characteristics. We also wanted to compare our sample to a sample from the general population with regard to HRQoL. Methods. This was a 3-month follow-up of 71 patients who started OAT. Measurements of HRQoL with EQ-5D (an instrument developed by the EuroQol group) were made at baseline and at three months. Results. Mean EQ-5D VAS (visual analogue scale) for the study sample at baseline was 47.3, which was lower than a Swedish reference population reporting 83.3. Individuals reporting being prescribed a drug for a psychiatric condition had significantly lower EQ-5D index values. Improvement in EQ-5D index score was significantly less for individuals reporting previous overdoses (-0.10, p=0.025). Individuals reporting previous suicide attempts had significantly lower EQ-5D VAS score at baseline. A significant increase of the EQ-5D VAS difference over time was found with a mean difference of 10.94 (p=0.008) for the total sample. Conclusion. To our knowledge this is the first time HRQoL as an outcome is reported in a population transferred from a NEP to OAT. Our results indicate that OAT can result in increased HRQoL, even with this type of rapid low-threshold referral.
机译：背景。据报道，用于治疗海洛因依赖的阿片类激动剂治疗（OAT）可改善整体健康状况并降低死亡率。药物的使用和在治疗中的保留经常被用作治疗成功的指标。然而，最近，研究人员建议，生活质量的测量应作为药物使用治疗评估的结果。在最近的一项随机对照试验中，我们证明了从针头交换程序（NEP）到OAT快速成功转诊的成功率很高。这项研究的目的是观察开始OAT后3个月的随访是否可以看到健康相关生活质量（HRQoL）的改善，以及是否与任何基线特征有关。我们还想将我们的样本与HRQoL方面的样本进行比较。方法。这是对开始OAT的71例患者的3个月随访。在基线和三个月时使用EQ-5D（由EuroQol组开发的仪器）对HRQoL进行测量。结果。研究样本在基线时的平均EQ-5D VAS（视觉模拟量表）为47.3，低于瑞典参考人群的83.3。报告患有精神病药物的个体的EQ-5D指数值明显较低。报告先前用药过量的个体的EQ-5D指数得分的改善明显较少（-0.10，p = 0.025）。报告先前自杀未遂的个体在基线时的EQ-5D VAS评分明显较低。发现EQ-5D VAS差异随时间显着增加，总样品的平均差异为10.94（p = 0.008）。结论。据我们所知，这是第一次将HRQoL作为结果从NEP转移到OAT的人群。我们的结果表明，即使使用这种快速的低阈值转诊，OAT也会导致HRQoL升高。

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