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首页> 外文期刊>Journal of Addiction >A Preliminary Study of Functional Brain Activation among Marijuana Users during Performance of a Virtual Water Maze Task
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A Preliminary Study of Functional Brain Activation among Marijuana Users during Performance of a Virtual Water Maze Task

机译：虚拟水迷宫任务执行过程中大麻使用者中功能性大脑激活的初步研究

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Numerous studies have reported neurocognitive impairments associated with chronic marijuana use. Given that the hippocampus contains a high density of cannabinoid receptors, hippocampal-mediated cognitive functions, including visuospatial memory, may have increased vulnerability to chronic marijuana use. Thus, the current study examined brain activation during the performance of a virtual analogue of the classic Morris water maze task in 10 chronic marijuana (MJ) users compared to 18 nonusing (NU) comparison subjects. Imaging data were acquired using blood oxygen level-dependent (BOLD) functional MRI at 3.0 Tesla during retrieval (hidden platform) and motor control (visible platform) conditions. While task performance on learning trials was similar between groups, MJ users demonstrated a deficit in memory retrieval. For BOLD fMRI data, NU subjects exhibited greater activation in the right parahippocampal gyrus and cingulate gyrus compared to the MJ group for the Retrieval-Motor Control contrast (NU > MJ). These findings suggest that hypoactivation in MJ users may be due to differences in the efficient utilization of neuronal resources during the retrieval of memory. Given the paucity of data on visuospatial memory function in MJ users, these findings may help elucidate the neurobiological effects of marijuana on brain activation during memory retrieval.
机译：许多研究已经报告了与慢性大麻使用相关的神经认知障碍。鉴于海马含有高密度的大麻素受体，海马介导的认知功能（包括视觉空间记忆）可能会增加对慢性大麻使用的脆弱性。因此，当前的研究在10位慢性大麻（MJ）用户与18位非使用（NU）比较对象相比的情况下，在模拟经典莫里斯水迷宫任务的虚拟模拟执行过程中检查了大脑的激活情况。在检索（隐藏平台）和运动控制（可见平台）条件下，使用血氧水平依赖性（BOLD）功能MRI在3.0 Tesla采集成像数据。虽然两组之间的学习试验任务表现相似，但MJ用户表现出记忆检索不足。对于BOLD fMRI数据，与MJ组相比，NU受试者在右海马旁回和扣带回的激活程度更高（取回运动对照）（NU> MJ）。这些发现表明，MJ用户的过度激活可能是由于在记忆检索过程中神经元资源的有效利用方面的差异。鉴于MJ用户的视觉空间记忆功能的数据很少，这些发现可能有助于阐明大麻在记忆检索过程中对大脑激活的神经生物学作用。

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