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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Growth hormone, insulin-like growth factor 1, and insulin signaling—a pharmacological target in body wasting and cachexia
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Growth hormone, insulin-like growth factor 1, and insulin signaling—a pharmacological target in body wasting and cachexia

机译：生长激素，类胰岛素生长因子1和胰岛素信号传导-人体消瘦和恶病质的药理目标

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摘要

Cachexia is an irreversible process that can develop in the course of chronic disease. It is characterized by the remodeling of the metabolic, inflammatory, and endocrine pathways. Insulin, growth hormone (GH), and insulin-like growth factor 1 (IGF-1) are involved in glucose, protein, and fat metabolism, which regulates body composition. In body wasting and cachexia, their signaling is impaired and causes anabolic/catabolic imbalance. Important mechanisms include inflammatory cytokines and neurohormonal activation. Remodeled post-receptor insulin, GH, and IGF-1 pathways constitute a potential target for pharmacological treatment in the setting of body wasting and cachexia. Peroxisome proliferator-activated receptor gamma agonists, drugs inhibiting angiotensin II action (angiotensin II antagonists and inhibitors of angiotensin-converting enzyme), and testosterone, which interfere with post-receptor pathways of insulin, GH, and IGF-1, were investigated as pharmacological intervention targets and various clinically important implications were reported. There are several other potential targets, but their treatment feasibility and applicability is yet to be established.
机译：恶病质是在慢性疾病过程中可能发展的不可逆过程。其特征在于代谢，炎症和内分泌途径的重塑。胰岛素，生长激素（GH）和类胰岛素生长因子1（IGF-1）与葡萄糖，蛋白质和脂肪代谢有关，后者可调节人体成分。在身体消瘦和恶病质中，它们的信号传导受损，并导致合成代谢/分解代谢失衡。重要机制包括炎性细胞因子和神经激素激活。改造后的受体胰岛素，GH和IGF-1途径构成了在身体消瘦和恶病质中进行药物治疗的潜在目标。作为药理学研究过氧化物酶体增殖物激活受体γ激动剂，抑制血管紧张素II作用的药物（血管紧张素II拮抗剂和血管紧张素转化酶抑制剂）和睾丸激素，它们干扰胰岛素，GH和IGF-1的受体后途径。报告了干预目标和各种临床重要意义。还有其他一些潜在目标，但是它们的治疗可行性和适用性尚待确定。

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