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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Expression of fascin_1 protein in cancer tissues of patients with nonsmall cell lung cancer and its relevance to patients' clinicopathologic features and prognosis
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Expression of fascin_1 protein in cancer tissues of patients with nonsmall cell lung cancer and its relevance to patients' clinicopathologic features and prognosis

机译：fascin_1蛋白在非小细胞肺癌患者癌组织中的表达及其与临床病理特征和预后的关系

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Objective: The aim of this study is to explore the expression of Fascin_1 protein in cancer tissues of patients with nonsmall cell lung cancer (NSCLC) and its relevance to patients' clinicopathologic features and prognosis. Methods: Retrospective analysis was performed on 81 patients with NSCLC who were admitted to our hospital and received surgical treatment from February 2012 to March 2016. To analyze the correlation of Fascin_1 protein expression in cancer tissues with the clinicopathologic features and prognosis of the patients, the immuno-histochemical method was applied to examine Fascin_1 protein expression in cancer and normal paracarcinoma tissues of the included 81 NSCLC patients. Results: Fascin_1 protein was diffused in cancer tissues, and cancer cells surrounding the carcinoma lesions were strongly stained. The protein was mainly located on the cytoplast or membrane of positive cells and manifested as a focal or diffuse brown granular distribution. The negative, weakly positive, and strongly positive expression rates in cancer tissues were 23.5% (19/81), 35.8% (29/81), and 40.7% (33/81), respectively. The negative, weakly positive, and strongly positive expression rates in paracarcinoma tissues were 71.6% (58/81), 12.3% (10/81), and 16% (13/81), respectively. The difference was statistically significant (P P P P P > 0.05). The median survival times for patients with positive Fascin_1 and negative Fascin_1 expression in cancer tissues were 26 and 44 months, respectively, indicating that the median survival time of the Fascin_1-positive group was significantly lower than that of in the Fascin_1-negative group (heart rate = 2.74, 95% confidence interval: 1.32–6.87, P Conclusions: Fascin_1 protein expression in NSCLC tissues and normal paracarcinoma issues were different. Fascin_1 expression in cancer tissues was related to the poor prognosis of NSCLC patients.
机译：目的：研究Fascin_1蛋白在非小细胞肺癌（NSCLC）患者癌组织中的表达及其与患者临床病理特征和预后的关系。方法：回顾性分析2012年2月至2016年3月我院收治并手术治疗的81例非小细胞肺癌患者的临床特征。分析Fascin_1蛋白在癌组织中的表达与患者临床病理特征及预后的关系。免疫组化法检测了包括81例NSCLC患者的癌组织和正常癌旁组织中Fascin_1蛋白的表达。结果：Fascin_1蛋白弥散在癌组织中，癌灶周围的癌细胞被强烈染色。该蛋白质主要位于阳性细胞的细胞质或膜上，表现为局灶性或弥散性褐色颗粒分布。癌组织中的阴性，弱阳性和强阳性表达率分别为23.5％（19/81），35.8％（29/81）和40.7％（33/81）。癌旁组织中的阴性，弱阳性和强阳性表达率分别为71.6％（58/81），12.3％（10/81）和16％（13/81）。差异具有统计学意义（P P P P P> 0.05）。癌组织中Fascin_1表达阳性和Fascin_1表达阴性的患者的中位生存时间分别为26和44个月，这表明Fascin_1阳性组的中位生存时间明显低于Fascin_1阴性组（心脏比率= 2.74，95％置信区间：1.32–6.87，P结论：NSCLC组织中Fascin_1蛋白的表达与正常癌旁组织不同，癌组织中Fascin_1表达与NSCLC患者预后差有关。

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