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首页> 外文期刊>Journal of Advances in Internal Medicine >Insulin Resistance in firstborn offspring of mother who developed diabetes later in fourth decade: Are both related to possible maternal malnutrition?
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Insulin Resistance in firstborn offspring of mother who developed diabetes later in fourth decade: Are both related to possible maternal malnutrition?

机译：母亲在第四十年后期患糖尿病的长子后代中的胰岛素抵抗：两者均与可能的母体营养不良有关吗？

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Back grounds and Aims: Diabetes mellitus is increasing each day. We aimed to study the insulin resistance (IR) in the offspring of people with diabetes and its relation with lifestyle and clinical factors.Methods: This is a cross sectional study of IR in offspring over the age of 18 years and having parents with diabetes. Participants already diagnosed as having diabetes, suffering from any illness or using drugs that may have altered blood sugar levels were excluded. A fasting blood sample was taken for blood glucose and serum insulin level and IR was calculated using homeostatic model assessment for IR (HOMA –IR).Results: Forty nine participants volunteered for the study of which 24.5% were found to have IR, the cut off value of HOMA –IR being 2.48. As compared to the later born offspring, the firstborn were six times more at risk for IR (Odds ratio 6.25, P value 0.015) and after adjustment for BMI, it was seven times (Odds ratio 7.29 , P value 0.011). IR was more in offspring with maternal diabetes than with paternal one. The mean age of diagnosis of diabetes in mothers having firstborn offspring with IR was 38.5 years as compared to 48.2 years of those having firstborn offspring without IR.Conclusion: Higher risk of IR seen in the firstborn offspring whose mother later developed diabetes at fourth decade indicate the probability of relation of both conditions with possible maternal malnutrition during the first pregnancy. Further larger studies are required focusing on these aspects.Journal of Advances in Internal Medicine 2014;3(2):56-61
机译：背景和目的：糖尿病每天都在增加。我们旨在研究糖尿病人后代的胰岛素抵抗（IR）及其与生活方式和临床因素的关系。方法：这是一项横断面研究，涉及18岁以上且有糖尿病父母的后代的IR。已经诊断出患有糖尿病，患有任何疾病或使用可能改变血糖水平的药物的参与者被排除在外。空腹抽取血液样本中的血糖和血清胰岛素水平，并使用稳态模型评估IR（HOMA –IR）来计算IR。结果：49名自愿参加研究的参与者中24.5％被发现患有IR， HOMA –IR的关闭值为2.48。与后代的后代相比，长子的患IR的几率高出六倍（几​​率6.25，P值0.015），而对BMI进行调整后，这是七倍（几率7.29，P值0.011）。孕产妇糖尿病的后代中IR的发生率高于父亲。具有IR的长子后代的母亲的平均糖尿病诊断年龄为38.5岁，而没有IR的长子后代的母亲的平均诊断年龄为48.2岁。结论：母亲在第四个十年后患上糖尿病的长子后代患IR的风险较高。这两种情况与第一次怀孕期间可能的孕产妇营养不良相关的可能性。还需要针对这些方面进行更大的研究。内科学进展2014; 3（2）：56-61

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