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首页> 外文会议>Nestle? Nutrition Workshop >Influence of Maternal Vitamin B_(12) and Folate on Growth and Insulin Resistance in the Offspring
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Influence of Maternal Vitamin B_(12) and Folate on Growth and Insulin Resistance in the Offspring

机译：母体维生素B_（12）和叶酸对后代生长和胰岛素抵抗的影响

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The burden of chronic noncommunicable diseases (NCDs) such as diabetes, obesity and cardiovascular disease is shifting rapidly to low- and middle-income countries. It calls for a review of the classic 'dogma' of genetic predisposition, precipitated by adult lifestyle. The paradigm of early life origins of chronic disease has focused attention on maternal health and nutrition as major determinants of the health of the offspring. India has high burden of maternal ill health and also of diabetes and cardiovascular disease, offering unique opportunities to study the links between the two. Pune studies showed that the Indian babies were thin but fat (mote adipose) compared to European babies, and that maternal micro-nutrient status during pregnancy was a determinant of offspring size and body composition. Two thirds of the mothers had low vitamin B_(12) concentrations, while folate deficiency was rare. Higher circulating concentrations of homocysteine predicted smaller baby size. Follow-up studies revealed that higher maternal folate in pregnancy predicted higher adiposity and insulin resistance in the child at 6 years of age, and that low maternal vitamin B_(12) exaggerated the risk of insulin resistance. Low maternal vitamin B_(12) status is also associated with increased risk of neural tube defects and poor offspring cognitive functions. Our results suggest an important role for maternal one-carbon metabolism in offspring growth and programming of NCD risk. These ideas are supported by animal studies. Improvement of adolescent nutrition could effect intergenerational prevention of chronic diseases.
机译：慢性非传染性疾病（NCD）如糖尿病，肥胖症和心血管疾病的负担在低收入和中等收入国家迅速转移。呼吁审查遗传易感性的经典“教条”，由成人生活方式倾诉。慢性病早期生命起源的范式集中了对产妇健康和营养的关注，作为后代健康的主要决定因素。印度具有孕妇生病健康和糖尿病和心血管疾病的负担，提供了独特的研究两者之间的联系。浦那的研究表明，与欧洲婴儿相比，印度婴儿薄但脂肪（MOTE脂肪），怀孕期间的母体微养分状况是后代大小和身体组成的决定因素。三分之二的母亲患有低维生素B_（12）浓度，而叶酸缺乏是罕见的。循环浓度高于较小的婴儿大小。后续研究表明，妊娠中较高的母体叶酸预测孩子6岁的孩子肥胖和胰岛素抗性，并且低产妇维生素B_（12）夸大了胰岛素抵抗的风险。低母体维生素B_（12）状态也与神经管缺陷的风险增加和后代认知功能的风险增加。我们的结果表明，母体单碳代谢在后代增长和NCD风险规划的重要作用。动物研究支持这些想法。青少年营养的改善可以实现跨性疾病的代际预防。

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