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Roles of noncoding RNAs in metastasis of nonsmall cell lung cancer: A mini review

机译:非编码RNA在非小细胞肺癌转移中的作用:综述

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Recent advances in genome-wide sequencing and gene expression profiling technologies has facilitated the discovery of a huge amount of long noncoding RNA (lncRNA) transcripts. In general, these lncRNAs have been reported to participate in multiple biological processes and human diseases through transcriptional, posttranscriptional and epigenetic pathway. Furthermore, emerging evidence has suggested that dysregulation of lncRNA contributes to the development and progression of human malignancies, notably lung cancer, which is one of the leading causes of cancer-related death. In this review, we will summarize the functions of lncRNAs from recent reports in human nonsmall cell lung cancer (NSCLC) research, especially in the metastasis of NSCLC, and highlight the future opportunities and challenges in diagnostics and therapy of NSCLC patients.
机译:全基因组测序和基因表达谱技术的最新进展促进了大量长非编码RNA(lncRNA)转录本的发现。通常,已经报道这些lncRNA通过转录,转录后和表观遗传途径参与多种生物学过程和人类疾病。此外,越来越多的证据表明,lncRNA的失调会导致人类恶性肿瘤(尤其是肺癌)的发生和发展,而肺癌是癌症相关死亡的主要原因之一。在这篇综述中,我们将总结人类非小细胞肺癌(NSCLC)研究中最近报告中lncRNA的功能,特别是在NSCLC转移方面的作用,并重点介绍NSCLC患者诊断和治疗方面的未来机遇和挑战。

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