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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Evaluation of the relationship of erythrocyte membrane Na+/K+-ATPase enzyme activity and tumor response to chemoradiotherapy in patients diagnosed with locally advanced nonsmall cell lung cancer and glioblastoma multiforme
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Evaluation of the relationship of erythrocyte membrane Na+/K+-ATPase enzyme activity and tumor response to chemoradiotherapy in patients diagnosed with locally advanced nonsmall cell lung cancer and glioblastoma multiforme

机译：评价局部晚期非小细胞肺癌和多形性胶质母细胞瘤患者红细胞膜Na + / K + -ATPase酶活性与肿瘤反应对放化疗的关系

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Context: Radiotherapy is the commonly used therapeutic modality for inoperable cancer types. We investigated chemoradiotherapy (CRT) effects on the Na +/K +-ATPase enzyme. Aims: The aim of the present study was to determine the usefulness of Na +/K +-ATPase enzyme as a prognostic factor and as a potential target for increasing the CRT response of nonsmall cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Settings and Design: We prospectively evaluated 30 patients (all were treated with CRT) and 20 healthy controls. Subjects and Methods: Blood samples were taken before and after the completion of CRT from the patients and once from the control group. Erythrocyte membranes were isolated and Na +/K +-ATPase enzyme activities were measured. Statistical Analysis Used: The statistical significance was calculated using the one-way analysis of variance test and the Tukey's test. Results: Na +/K +-ATPase activity levels were increased in the patient groups before completion of CRT CRT, when compared to the control group. A significant decrease in Na +/K +-ATPase activity was noted in the patient groups after the completion of CRT when compared to before CRT, but the activity remained higher than in the control group. No relationship was noted between survival and Na +/K +-ATPase activity in NSCLC and GBM patients. Conclusion: Levels of Na +/K +-ATPase activity were initially high in patients with NSCLC and GBM, and decreased after the completion of CRT. This supports a linkage between the altered activity of Na +/K +-ATPase and the treatment effects of CRT. The observed change in Na +/K +-ATPase activity in cancer patients receiving CRT suggests that targeting this enzyme could represent a novel mean of combatting NSCLC and GBM.
机译：背景：放射疗法是无法手术的癌症类型的常用治疗方法。我们研究了放疗（CRT）对Na + / K + -ATPase酶的影响。目的：本研究的目的是确定Na + / K + -ATPase酶作为预后因素和增加CRT反应的潜在靶点的有用性非小细胞肺癌（NSCLC）和多形胶质母细胞瘤（GBM）。设置和设计：我们前瞻性评估了30例患者（均接受了CRT治疗）和20例健康对照。研究对象和方法：在完成CRT之前和之后，分别从患者和对照组一次采集血样。分离红细胞膜并测定Na + / K + -ATPase的酶活性。使用的统计分析：使用方差检验和Tukey检验的单向分析计算统计显着性。结果：与对照组相比，CRT CRT完成前患者组的Na + / K + -ATPase活性水平升高。与CRT前相比，在完成CRT后的患者组中，Na + / K + -ATPase活性显着降低，但活性仍高于对照组。 NSCLC和GBM患者的生存率与Na + / K + -ATPase活性之间没有关系。结论：NSCLC和GBM患者的Na + / K + -ATPase活性最初较高，而在完成CRT后下降。这支持了Na + / K + -ATPase活性的改变与CRT的治疗作用之间的联系。在接受CRT的癌症患者中观察到的Na + / K + -ATPase活性的变化表明，靶向该酶可能代表了对抗NSCLC和GBM的新手段。

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