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首页> 外文期刊>Journal of Cancer Research and Treatment >Study of Immune Effector Cells in Leukoplakia and Oral Cancer
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Study of Immune Effector Cells in Leukoplakia and Oral Cancer

机译：白斑和口腔癌免疫效应细胞的研究

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Aim: Immunosuppresion in oral squamous cell carcinoma (OSCC) is related to high degree of recurrence and believed to develop from premalignant lesion. Leukocytes especially T cell subsets are important in immune surveillance during malignant transformation. This study has been planned to observe changes in systemic immune response in premalignant and malignant oral lesions. Method: The proportions of Neutrophils, Monocytes, Lymphocytes, total T cells, T cell subsets including αβ/γδ T cells, Cytotoxic T cells, Helper T cells, Naive/ Effector/Memory T cells, Regulatory T cells and NK-T subpopulations were analysed in peripheral circulation of healthy donors (N= 49), Leukoplakia (N=20) and OSCC patients (N=100) by flowcytometry. Results: In comparison with healthy donors, decreased Lymphocytes, Naive Helper cells, NK T subpopulations and increased Effector cells were observed in Leukoplakia patients. Similarly, decreased Lymphocytes, NK T subpopulations and increased Neutrophils, Monocytes, Helper and Regulatory T cells were observed in OSCC patients as compared to healthy controls. Moreover, Lymphocytes were decreased and Regulatory T cells were increaed during the progression of Leukoplakia to OSCC. Further, in relation with clinicopathological parameters, Cytotoxic cells were found to be reduced with increasing histological grade. Also, Helper cells were found to be decreased in patients with tobacco and alcohol habit and also with increasing tumor size. Further, in univariate survival analysis, increased incidence of relapse was observed in patients with low γδ and NK T cells. In multivariate survival analysis, low γδ T cells emerged as poor prognosticator for disease free survival and high Regulatory T cells emerged as poor prognosticator for predicting overall survival. Conclusion: Altered systemic immune response was seen during malignant transformation and also found to be associated with patient’s survival. Thus, investigation of circulating Leukocyte and T cell subsets seems to be useful for predicting patient’s survival and to identify immunosuppressed patients who may be benefited with immunotherapy.
机译：目的：口腔鳞状细胞癌（OSCC）的免疫抑制与高度复发有关，并被认为是由癌前病变发展而来的。白细胞特别是T细胞亚群在恶性转化过程中的免疫监视中很重要。计划进行这项研究以观察恶性前和恶性口腔病变中全身免疫反应的变化。方法：中性粒细胞，单核细胞，淋巴细胞，总T细胞，包括αβ/γδT细胞，细胞毒性T细胞，辅助T细胞，幼稚/效应/记忆T细胞，调节性T细胞和NK-T亚群的T细胞亚群的比例通过流式细胞仪分析了健康供体（N = 49），白斑（N = 20）和OSCC患者（N = 100）的外周血。结果：与健康供体相比，白斑患者观察到淋巴细胞，幼稚辅助细胞，NK T亚群减少和效应细胞增加。同样，与健康对照组相比，在OSCC患者中观察到淋巴细胞减少，NK T亚群减少，嗜中性粒细胞，单核细胞，辅助性和调节性T细胞增加。此外，在白斑发展为OSCC的过程中，淋巴细胞减少并且调节性T细胞增加。此外，关于临床病理参数，发现细胞毒性细胞随着组织学等级的提高而减少。此外，发现吸烟和酗酒习惯患者的辅助细胞减少，并且肿瘤大小增加。此外，在单变量生存分析中，低γδ和NK T细胞患者的复发率增加。在多变量生存分析中，低γδT细胞表现为无病生存的不良预后，高调节性T细胞表现为预测整体生存的不良预后。结论：恶性转化过程中发现全身免疫反应改变，并且与患者的生存有关。因此，对循环中的白细胞和T细胞亚群的研究对于预测患者的存活率以及确定免疫抑制患者可能有益于免疫治疗很有用。

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