Tumor Protein p53: Novel Aspects of an Old Tumor Marker

Ahmed M. Kabel

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Tumor Protein p53: Novel Aspects of an Old Tumor Marker

机译：肿瘤蛋白p53：旧肿瘤标记物的新颖方面

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P53 gene is a tumor suppressor gene that stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from his parents, he will be predisposed to cancer and usually develop several tumors in various tissues in early adulthood. However, mutations in p53 are found in most tumor types, and so contribute to a number of molecular events leading to tumor formation. There are numerous informations that exist on all aspects of p53 normal function and mutant expression in human cancers, reflecting its key role in the pathogenesis of human cancers.

机译：P53基因是阻止肿瘤形成的抑癌基因。如果一个人仅从其父母那里继承p53基因的一个功能性拷贝，那么他将容易患癌症，并且通常在成年初期会在各种组织中发展出多种肿瘤。然而，在大多数肿瘤类型中都发现了p53的突变，因此导致许多导致肿瘤形成的分子事件。关于人类癌症中p53正常功能和突变体表达的各个方面存在大量信息，反映了其在人类癌症发病机理中的关键作用。

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《Journal of Cancer Research and Treatment》 |2015年第2期|共3页
作者
Ahmed M. Kabel;
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中图分类肿瘤学;
关键词
p53tumormarker;

机译：p53肿瘤标志物;

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专利

1. CSHL study shows that malignant tumors can be shut down after all Aggressive tumors lacking p53 protein stop dead in their tracks when p53's sister protein-TAp63-steps in [J] . Alea Mills Cancer biology & therapy . 2009,第22期

机译：CSHL研究表明，当所有缺乏p53蛋白的侵袭性肿瘤停止死亡时，p53的姊妹蛋白-TAp63逐步转移，恶性肿瘤可以关闭。
2. Pure versus combined Merkel. cell carcinomas: immunohistochemical evaluation of cellular proteins (p53, Bcl-2, and c-kit) reveals significant overexpression of p53 in combined tumors [J] . Lai Jonathan H., Fleming Kirsten E., Ly Thai Yen, Human Pathology . 2015,第9期

机译：纯与合并的默克尔。细胞癌：细胞蛋白（p53，Bcl-2和c-kit）的免疫组织化学评估显示，合并肿瘤中p53明显过表达
3. Infrequent p53 Gene Mutations and Lack of p53 Protein Expression in Clear Cell Sarcoma of the Kidney: Immunohistochemical Study and Mutation Analysis of p53 in Renal Tumors of Unfavorable Prognosis [J] . Chuen Hsueh, Hao Wang, Frank Gonzalez-Crussi, Modern Pathology . 2002,第6期

机译：肾透明细胞肉瘤中罕见的p53基因突变和p53蛋白表达的缺乏：肾肿瘤中预后不良的p53免疫组织化学研究和突变分析
4. Clustering Protein-Protein Interaction Network of TP53 Tumor Suppressor Protein using Markov Clustering Algorithm [C] . Thia Sabel Permata, Alhadi Bustamam International Conference on Advanced Computer Science and Information Systems . 2015

机译：使用Markov聚类算法的TP53肿瘤抑制蛋白的聚类蛋白 - 蛋白质相互作用网络
5. HBx-mediated disruption ofp53 tumor suppressor protein function leading to re-activation of a silenced tumor marker gene. [D] . Ogden, Stacey Kathryn. 2002

机译：HBx介导的p53肿瘤抑制蛋白功能的破坏，导致沉默的肿瘤标志物基因重新激活。
6. Proteins in Body Fluids Amino Acids and Tumor Markers: Diagnostic and Clinical Aspects [O] . M Adinolfi 1984

机译：体液氨基酸和肿瘤标志物中的蛋白质：诊断和临床方面
7. Tumores da córtex da supra-renal: o uso do p53 na diferenciação entre carcinomas e adenomas Adrenocortical tumors: use of p53 protein to discriminate carcinomas from adenomas [O] . Rodrigo A. R. Falconi, Antonio C. P. Martins, Maria A. L. Velludo, 2000

机译：肾上腺皮质肿瘤：利用p53蛋白区分癌与肾上腺皮质腺瘤：利用p53区分癌和腺瘤

Tumor Protein p53: Novel Aspects of an Old Tumor Marker

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