Overview of Research and Development for Anticancer Drugs

Junjie Xu; Wenwei Mao

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Overview of Research and Development for Anticancer Drugs

机译：抗癌药研究开发概况

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Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.

机译：就项目数量，临床试验和支出而言，抗癌药物的研发一直是制药行业最大的市场领域。在过去的10到30年中，针对癌症的靶向治疗得到了发展，并通过将一些以前致命的恶性肿瘤转变为可长期控制的疾病取得了巨大的临床效果，但治愈问题仍然存在。这份小型综述概述了抗癌药物开发的当前状态，并提出了有关如何进一步提高癌症发现的准确性和功效的观点。

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《Journal of Cancer Therapy》 |2016年第10期|共11页
作者
Junjie Xu; Wenwei Mao;
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中图分类肿瘤学;
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2. Development of EGFR Family Small Molecule Inhibitors for Anticancer Intervention: An Overview of Approved Drugs and Clinical Candidates [J] . Cheng Weiyan, Hu Yongzhou, Sheng Rong Current medicinal chemistry . 2014,第38期

机译：EGFR家庭小分子抑制剂抗癌干预的发展：批准的药物和临床候选人的概述。
3. Anticancer drug development from traditional cytotoxic to targeted therapies: Evidence of shorter drug research and development time, and shorter drug lag in Japan [J] . Kawabata-ShodaE., MasudaS., KimuraH. Journal of Clinical Pharmacy and Therapeutics . 2012,第5期

机译：从传统的细胞毒素到靶向疗法的抗癌药物开发：证据表明缩短了药物研发时间，缩短了日本的药物滞后
4. EFFECT OF DRUG LOADING IN ANTICANCER POLYMER-DRUG CONJUGATE ON INTERACTIONS WITH CELLS AND ENZYMATIC RELEASE OF DRUG [C] . R. Prakash, V. Omelyanenko, C. Anderson, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

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5. Drug development of targeted anticancer drugs based on PK/PD investigations [D] . Wang, Shining 2008

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6. Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs [O] . Phuong Tran, Yong-Chul Pyo, Dong-Hyun Kim, 2019

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7. The changing world of drug development: an academic research organization's perspective on the "Seven Wonders" of the future world of anticancer drug development [O] . Liu, Yan, Lacombe, Denis, Stupp, Roger 2014

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Overview of Research and Development for Anticancer Drugs

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