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首页> 外文期刊>Journal of Cardiovascular Disease Research >Effect on Certain Infl ammatory Markers in Uncontrolled Diabetic Patients of North-West Indian
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Effect on Certain Infl ammatory Markers in Uncontrolled Diabetic Patients of North-West Indian

机译：对西北印度裔未控制糖尿病患者某些炎症指标的影响

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Background: Diabetes is the chronic disorder resulting from a number of factors in which an absolute or relative defi ciency of insulin or its function occurs. It has emerged as a major public health problem in India. The risk of coronary artery disease (CAD) among Indian diabetic population is 2-4 times higher than that of non-diabetic subjects. The infl ammatory markers such as C-reactive proteins (CRPs), fi brinogen, interleukin-4, homocysteine have been recognized as an independent risk factor for CAD. Aim: The aim was to evaluate the infl ammatory markers for early detection of CAD in diabetics. Materials and Methods: In the present study, 50 diabetic patients (both sexes) with raised glycosylated hemoglobin in the age range of 50-65 years and equal number of age and gender matched normal healthy subjects (control) were recruited. The levels of plasma CRP, fi brinogen, homocysteine along with various lipoproteins were evaluated in uncontrolled diabetic patients. Results: The levels of total cholesterol, triglycerides, very-low-density lipoprotein (LDL)-cholesterol and LDL-cholesterol signifi cantly increased while high-density lipoprotein-cholesterol levels were signifi cantly decreased in serum of diabetic patients in comparison to normal healthy control subjects. A signifi cant increase in the CRP (P < 0.001), fi brinogen (P < 0.001), and homocysteine (P < 0.01) levels in diabetic patients with respect to control subjects was observed. Conclusion: This study therefore suggests the importance of assessing infl ammatory markers along with other routine investigations in diabetic patients in addition to primary and secondary preventives measures to migrate the devastating consequences of diabetes leading to CAD. This strategy may help to identify and monitor high-risk diabetic for any cardiovascular event thereby reducing the economic burden and improving the quality of life.
机译：背景：糖尿病是一种慢性疾病，由多种因素引起，其中发生胰岛素绝对或相对缺乏或其功能。它已成为印度主要的公共卫生问题。印度糖尿病人群中冠状动脉疾病（CAD）的风险是非糖尿病患者的2-4倍。诸如C反应蛋白（CRP），纤维蛋白原，白介素4，同型半胱氨酸等充气标记物已被认为是CAD的独立危险因素。目的：目的是评估糖尿病患者早期检测冠状动脉炎的通气标记物。材料和方法：在本研究中，招募了50名糖尿病患者（男女），其糖化血红蛋白升高，年龄在50-65岁之间，并且年龄和性别相等的正常健康受试者（对照组）。在不受控制的糖尿病患者中评估血浆CRP，纤维蛋白原，高半胱氨酸以及各种脂蛋白的水平。结果：与正常健康人相比，糖尿病患者血清中的总胆固醇，甘油三酸酯，极低密度脂蛋白（LDL）-胆固醇和LDL-胆固醇水平显着升高，而高密度脂蛋白-胆固醇水平显着降低控制对象。与对照组相比，糖尿病患者的CRP（P <0.001），纤维蛋白原（P <0.001）和高半胱氨酸（P <0.01）水平显着增加。结论：因此，这项研究表明，除了主要和次要的预防措施以转移导致糖尿病的严重后果导致冠心病之外，评估糖尿病患者的通气标记以及其他常规检查也很重要。该策略可能有助于识别和监测任何心血管事件的高危糖尿病患者，从而减轻经济负担并改善生活质量。

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