Triptolide: A new star for treating human malignancies

Ping Yan; Xiaotian Sun

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Triptolide: A new star for treating human malignancies

机译：雷公藤甲素：治疗人类恶性肿瘤的新星

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In recent years, cancer has become the most common human disease worldwide, and great attentions have been paid to clarifying the carcinogenesis and identifying new effective antitumor therapy. Although great progress has been made in this research field, human malignant diseases could still not be radically cured. Thunder god vine is a herbal medicine, which has proved to exert efficient antitumor activity in various human cancers such as lung cancer, pancreatic cancer, and colon cancer. In vivo and in vitro experiments showed that thunder god vine extract triptolide could inhibit tumor cell proliferation, cell migration, and cell invasion. Here, we overviewed the functional role of triptolide in human malignancies and its promising therapeutic potential in treating such deadly diseases.

机译：近年来，癌症已成为全球范围内最常见的人类疾病，并且人们已经非常关注阐明致癌作用和确定新的有效抗肿瘤治疗方法。尽管在该研究领域已经取得了很大的进步，但是人类的恶性疾病仍然不能被彻底治愈。雷神藤是一种草药，已被证明在多种人类癌症如肺癌，胰腺癌和结肠癌中发挥有效的抗肿瘤活性。体内和体外实验表明，雷神藤提取物雷公藤甲素可抑制肿瘤细胞的增殖，细胞迁移和细胞侵袭。在这里，我们概述了雷公藤甲素在人类恶性肿瘤中的功能作用及其在治疗这种致命疾病中的有希望的治疗潜力。

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《Journal of Cancer Research and Therapeutics》 |2018年第9期|共5页
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Ping Yan; Xiaotian Sun;
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中图分类肿瘤学;
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1. Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells. [J] . M Klawitter, L Quero, J Klasen, European spine journal: official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society . 2012,第Suppla6期

机译：雷公藤内酯醇具有抗炎，抗分解代谢和同化作用，并能抑制IL-1β处理的人椎间盘细胞中的TLR表达和MAPK活性。
2. Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells [J] . M. Klawitter, L. Quero, J. Klasen, European Spine Journal . 2012,第s6期

机译：雷公藤内酯醇具有抗炎，抗分解代谢和合成代谢作用，并能抑制IL-1β处理的人椎间盘细胞中TLR表达和MAPK活性
3. Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells [J] . European spine journal . 2012,第6期

机译：雷公藤内酯醇具有抗炎，抗分解代谢和合成代谢作用，并能抑制IL-1β处理的人椎间盘细胞中TLR表达和MAPK活性
4. Bio-molecular optimized interactions and conformational switches in human ERβ and SRC-1 protein: An in silico approach to suppress tumor in breast cancer malignancies: Computational insight for suppression of tumorigenesis in breast malignancies [C] . Arundhati Banerjee, Sujay Ray 2016 International Conference on Microelectronics, Computing and Communications . 2016

机译：人类ERβ和SRC-1蛋白中生物分子的优化相互作用和构象转换：抑制乳腺癌恶性肿瘤的计算机方法：抑制乳腺癌恶性肿瘤发生的计算机洞察
5. Cytometric detection of nuclear features associated with pre-malignancy or malignancy in human bronchial specimens [D] . Payne, Peter William. 1997

机译：流式细胞术检测与人类支气管标本中的恶变前或恶性肿瘤相关的核特征
6. Triptolide exhibits anti-inflammatory anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells [O] . M. Klawitter, L. Quero, J. Klasen, 2012

机译：雷公藤内酯醇具有抗炎抗分解代谢和合成代谢作用并能抑制IL-1β处理的人椎间盘细胞中TLR表达和MAPK活性
7. Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells [O] . Klawitter, M, Quero, L, Klasen, J, 2012

机译：雷公藤内酯醇具有抗炎，抗分解代谢和合成代谢作用，并能抑制IL-1β处理的人椎间盘细胞中TLR表达和MAPK活性

Triptolide: A new star for treating human malignancies

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