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首页> 外文期刊>Journal of Cardiovascular Disease Research >Role of Atherogenic Indices and Association of LPL Intron 6 Gene Polymorphism with Dyslipidemia Subtypes in the Prediction of Cardiovascular Risk
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Role of Atherogenic Indices and Association of LPL Intron 6 Gene Polymorphism with Dyslipidemia Subtypes in the Prediction of Cardiovascular Risk

机译：致动脉粥样硬化指数的血脂指数亚型和致脂指数的关联以及LPL内含子6基因多态性的关联

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Background and objectives: Dyslipidemia is renowned as a prominent risk factor for development of atherosclerosis and other cardiovascular disease. The aim study to estimation of lipid profile and predict the cardiovascular risk among the dyslipidemia subtypes and also determine the association of LPL intron 6 C T (rs285) gene polymorphisam in dyslipidemia subtypes. Methods: A total number of 258 subjects were participated in our study, in which 129 members were with elevated lipid profile considered as cases and 129 numbers with normal lipids considered as control subjects. Among the 129 cases, they are further divided into dyslipidemia subtypes. All the sample were further used for analysis of lipid profile and determined the gene polymorphsiam by RFLP. Results: In our study observed, elevated levels of lipid profile [TC (241.53±6.45), TGs (295.40±28.31), LDL-c (143.69±7.05), VLDL-c (59.08±5.66) and lower levels of HDL-c (39.70± 1.23) and higher values atherogenic indices in combined lipidemia type than the other types and controls. In genotype analysis was not showed significant association of intron 6 C T gene polymorphisma in both hypercholesterolemia [odd’s ratio: 0.77(0.33-1.79); 0.18(0.05-0.62); χ2 p: 0.025] and hyperlipidemia [odd’s ratio: 0.40 (0.14-1.12); 0.82 (0.33-2.03); χ2 p: 0.177] cases compared with control subjects. But observed, higher risk with CT and CC genotypes in both hypertriglyceridemia and combined dyslipidemia cases. In combined lipidema cases the comparison of lipid profile of genotypes, CC genotypes showed significantly elevated triglycrides (349.5±39.49; p T gene polymorphisam may be associated with elevated levels of triglycrdies and VLDL-c.
机译：背景与目的：血脂异常是动脉粥样硬化和其他心血管疾病发展的重要危险因素。该研究旨在评估血脂异常亚型中的脂质分布并预测心血管风险，并确定血脂异常亚型中LPL内含子6 C> T（rs285）基因多态性的关联。方法：总共258名受试者参加了我们的研究，其中129名具有较高血脂水平的成员被认为是病例，而129名具有正常血脂的成员被认为是对照组。在129例中，它们进一步分为血脂异常亚型。所有样品进一步用于脂质谱分析并通过RFLP确定基因多态性。结果：在我们的研究中，血脂水平升高[TC（241.53±6.45），TGs（295.40±28.31），LDL-c（143.69±7.05），VLDL-c（59.08±5.66）和HDL-c降低c（39.70±1.23）和组合血脂异常类型的动脉粥样硬化指数值高于其他类型和对照组。在基因型分析中，没有发现内含子6 C> T基因多态性与高胆固醇血症有显着相关性[比​​值：0.77（0.33-1.79）; 0.18（0.05-0.62）; χ2p：0.025]和高脂血症[比值比：0.40（0.14-1.12）; 0.82（0.33-2.03）; χ2p：0.177]。但是观察到，高甘油三酯血症和合并血脂异常的病例，CT和CC基因型的风险更高。在合并脂质肿的病例中，对基因型，CC基因型的脂质谱的比较显示甘油三酸酯显着升高（349.5±39.49; p T基因多态性可能与甘油三酸酯和VLDL-c水平升高有关。

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