• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Balkan journal of medical genetics: BJMG >ASSOCIATION OF THE APOLIPOPROTEIN A-I GENE POLYMORPHISMS WITH CARDIOVASCULAR DISEASE RISK FACTORS AND ATHEROGENIC INDICES IN PATIENTS FROM ASSAM, NORTHEAST INDIA
【24h】

ASSOCIATION OF THE APOLIPOPROTEIN A-I GENE POLYMORPHISMS WITH CARDIOVASCULAR DISEASE RISK FACTORS AND ATHEROGENIC INDICES IN PATIENTS FROM ASSAM, NORTHEAST INDIA

机译：Assam，印度东北部患者心血管蛋白A-I基因多态性与心血管疾病的危险因素和闭塞依据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cardiovascular disease (CVD) risk factors, and particularly decreased high density lipoprotein cholesterol (HDL-C) dyslipidemia are prevalent in Assam, India. This study was undertaken to investigate whether Apolipoprotein A-I (APOA1) gene polymorphisms (G-75A and C+83T) were associated with i) the risk for decreased HDL-C, and ii) other CVD risk factors, viz. serum lipids, atherogenic indices, obesity, and blood pressure (BP). A total of 649 subjects were screened, from which 200 eligible individuals, classified as case group with decreased HDL-C levels (100 subjects) and control group with normal HDL-C levels (100 subjects) were enrolled and genotyped using polymersase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing. Lipid fractions [HDL-C, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), triglycerides (TG)] and atherogenic indices [Castelli's Risk Indices-I and -II (CRI-I and -II), non-HDL-C fraction, atherogenic index of plasma (AIP), atherogenic coefficient (AC)] were estimated. The G-75A and C+83T loci were not associated with decreased HDL-C risk. This was confirmed across different genetic models (dominant, recessive, additive and allelic). Association was also absent with BP and obesity. However, the G-75A locus was associated with LDL-C, whereas the C+83T locus was associated with TG and VLDL-C. Furthermore, these sites had effects on atherogenic indices. The rare A allele at the G-75A locus was associated with adverse CRI-I, CRI-II, non-HDL-C and AC values, while the major C allele at the C+83T locus was associated with adverse AIP values. Thus, the pro-atherogenic G-75A polymorphism and the anti-atherogenic C+83T polymorphism represent important genetic loci that modulate CVD risk factors in subjects from Assam.
机译：心血管疾病（CVD）危险因素，特别是高密度脂蛋白胆固醇（HDL-C）血脂血症在印度普遍存在。本研究进行了研究载脂蛋白A-I（APOA1）基因多态性（G-75A和C + 83T）是否与I）有关的HDL-C和II）其他CVD危险因素的风险。血清脂质，血液发生指数，肥胖和血压（BP）。筛查总共649个受试者，其中200个符合条件的个体，分类为具有较低的HDL-C水平（100个受试者）和具有正常HDL-C水平的对照组（100个受试者）的案例组进行纳入和基因分型使用聚合物酶链式反应 - 限制性片段长度多态性（PCR-RFLP）和DNA测序。脂质级分[HDL-C，总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C），非常低密度脂蛋白胆固醇（VLDL-C），甘油三酯（TG）]和闭塞指数[Castelli的风险指标-I和 - 估计II（CRI-I和-II），非HDL-C级分，血浆（AIP）的致动脉粥样硬化指数，致动脉粥系数（AC）]。 G-75A和C + 83T基因座与降低的HDL-C风险无关。这是跨不同的遗传模型（显性，隐性，添加剂和等位基因）确认。联想也缺乏BP和肥胖症。然而，G-75A基因座与LDL-C相关，而C + 83T基因座与TG和VLDL-C相关联。此外，这些网站对动身索引有影响。 G-75A基因座的罕见等位基因与不良CRI-1，CRI-II，非HDL-C和AC值相关，而C + 83T基因座的主要C等位基因与不利的AIP值相关。因此，促致动脉粥样硬化G-75A多态性和抗动脉粥样菌C + 83T多态性代表了重要的遗传基因座，其调节来自ASSAM的受试者的CVD危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号