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首页> 外文期刊>Journal of cardiovascular magnetic resonance : >Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: Relationships with coronary disease severity
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Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: Relationships with coronary disease severity

机译：多峰心血管磁共振可量化冠心病患者血管结构和功能的区域变化：与冠心病严重程度的关系

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BackgroundCardiovascular magnetic resonance (CMR) of the vessel wall is highly reproducible and can evaluate both changes in plaque burden and composition. It can also measure aortic compliance and endothelial function in a single integrated examination. Previous studies have focused on patients with pre-identified carotid atheroma. We define these vascular parameters in patients presenting with coronary artery disease and test their relations to its extent and severity.Methods and Results100 patients with CAD [single-vessel (16%); two-vessel (39%); and three-vessel (42%) non-obstructed coronary arteries (3%)] were studied. CAD severity and extent was expressed as modified Gensini score (mean modified score 12.38 ± 5.3). A majority of carotid plaque was located in the carotid bulb (CB). Atherosclerosis in this most diseased segment correlated modestly with the severity and extent of CAD, as expressed by the modified Gensini score (R = 0.251, P < 0.05). Using the AHA plaque classification, atheroma class also associated with CAD severity (rho = 0.26, P < 0.05). The distal descending aorta contained the greatest plaque, which correlated with the degree of CAD (R = 0.222; P < 0.05), but with no correlation with the proximal descending aorta, which was relatively spared (R = 0.106; P = n. s.). Aortic distensibility varied along its length with the ascending aorta the least distensible segment. Brachial artery FMD was inversely correlated with modified Gensini score (R = -0.278; P < 0.05). In multivariate analysis, distal descending aorta atheroma burden, distensibility of the ascending aorta, carotid atheroma class and FMD were independent predictors of modified Gensini score.ConclusionsMultimodal vascular CMR shows regional abnormalities of vascular structure and function that correlate modestly with the degree and extent of CAD.
机译：背景技术血管壁的心血管磁共振（CMR）具有很高的重现性，可以评估斑块负荷和组成的变化。它还可以在一次综合检查中测量主动脉顺应性和内皮功能。先前的研究集中于预先确定的颈动脉粥样硬化患者。我们定义了冠心病患者的这些血管参数，并测试了它们与程度和严重程度之间的关系。方法与结果100例CAD患者[单血管（16％）;两船（39％）;和三支血管（42％）无阻塞的冠状动脉（3％）]进行了研究。 CAD严重程度和程度表示为改良的Gensini评分（平均改良评分为12.38±5.3）。大部分颈动脉斑块位于颈动脉球囊（CB）中。如修改后的Gensini评分所示，该患病最严重的部分的动脉粥样硬化与CAD的严重程度和程度相关性不大（R = 0.251，P <0.05）。使用AHA斑块分类，动脉粥样硬化类别也与CAD严重程度相关（rho = 0.26，P <0.05）。远端降主动脉的斑块最大，与CAD程度相关（R = 0.222; P <0.05），但与近端降主动脉没有相关性，后者相对较弱（R = 0.106; P = n。s。）。主动脉扩张性沿其长度变化，主动脉扩张性最小。肱动脉口蹄疫与Gensini评分改变呈负相关（R = -0.278; P <0.05）。在多变量分析中，远端降主动脉粥样硬化负担，升主动脉扩张性，颈动脉粥样硬化类别和FMD是Gensini评分改变的独立预测因素。结论多峰血管CMR显示了局部血管结构和功能异常，与CAD的程度和程度适度相关。

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