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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Does serum alkaline phosphatase level really indicate the prognosis in patients with osteosarcoma? A meta-analysis
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Does serum alkaline phosphatase level really indicate the prognosis in patients with osteosarcoma? A meta-analysis

机译：血清碱性磷酸酶水平是否真的指示骨肉瘤患者的预后？荟萃分析

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Objective: Osteosarcoma is the most common malignant bone tumor that occurs in children and adolescents. Various studies have investigated the role of serum alkaline phosphatase (ALP) level in patients with osteosarcoma but report conflicting findings. Thus, a meta-analysis to assess its prognostic value more precisely is conducted. Materials and Methods: Pooled hazard ratio (HR) with 95% confidence intervals (CIs) of overall survival (OS) was used to assess the prognostic role of serum ALP level. Eleven studies published between 1993 and 2013 with a total of 1336 osteosarcoma patients were included. Results: Overall, the pooled HR for all 11 eligible studies evaluating high ALP level on OS was 1.60 (95% CI: 1.38–1.86). Sensitivity analysis suggested that the pooled HR was stable and omitting a single study did not change the significance of the pooled HR. Begg's (0.553) and Egger's (0.382) test also did not suggest evidence for publication bias. Conclusion: This meta-analysis suggests that high serum ALP level is obviously associated with lower OS rate in patients with osteosarcoma, and it is an effective biomarker of prognosis.
机译：目的：骨肉瘤是儿童和青少年中最常见的恶性骨肿瘤。各种研究调查了血清碱性磷酸酶（ALP）水平在骨肉瘤患者中的作用，但报告了相互矛盾的发现。因此，进行了荟萃分析以更准确地评估其预后价值。材料和方法：合并总生存率（OS）为95％置信区间（CI）的合并危险比（HR）用于评估血清ALP水平的预后作用。在1993年至2013年之间发表的11项研究共纳入1336例骨肉瘤患者。结果：总体而言，所有11项评估OS高ALP水平的合格研究的合并HR为1.60（95％CI：1.38-1.86）。敏感性分析表明，合并的HR是稳定的，省略单个研究不会改变合并HR的意义。 Begg（0.553）和Egger（0.382）的检验也没有提供发表偏倚的证据。结论：这项荟萃分析表明，骨肉瘤患者血清ALP水平高与OS率降低明显相关，是预后的有效生物标志物。

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