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首页> 外文期刊>Journal of Clinical Medicine Research >Signaling Pathways in Thyroid Cancer and Their Therapeutic Implications
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Signaling Pathways in Thyroid Cancer and Their Therapeutic Implications

机译：甲状腺癌的信号通路及其治疗意义

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Thyroid cancer is a common malignancy of endocrine system, and has now become the fastest increasing cancer among all the malignancies. The development, progression, invasion, and metastasis are closely associated with multiple signaling pathways and the functions of related molecules, such as Src, Janus kinase (JAK)-signal transducers and activators of transcription (STAT), mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/Akt, NF-κB, thyroid stimulating hormone receptor (TSHR), Wnt-β-catenin and Notch signaling pathways. Each of the signaling pathways could exert its function singly or through network with other pathways. These pathways could cooperate, promote, antagonize, or interact with each other to form a complex network for the regulation. Dysfunction of this network could increase the development, progression, invasion, and metastasis of thyroid cancer. Inoperable thyroid cancer still has a poor prognosis. However, signaling pathway-related targeted therapies offer the hope of longer quality of meaningful life for this small group of patients. Signaling pathway-related targets provide unprecedented opportunities for further research and clinical development of novel treatment strategies for this cancer. In the present work, the advances in these signaling pathways and targeted treatments of thyroid cancer were reviewed.J Clin Med Res. 2016;8(4):284-296doi: http://dx.doi.org/10.14740/jocmr2480w
机译：甲状腺癌是内分泌系统常见的恶性肿瘤，现已成为所有恶性肿瘤中增长最快的癌症。发育，进展，侵袭和转移与多种信号通路和相关分子的功能密切相关，例如Src，Janus激酶（JAK）-信号转导子和转录激活子（STAT），促分裂原激活的蛋白激酶（MAPK） ），磷酸肌醇3激酶（PI3K）/ Akt，NF-κB，甲状腺刺激激素受体（TSHR），Wnt-β-catenin和Notch信号通路。每个信号通路可以单独发挥作用，也可以通过与其他通路的网络来发挥作用。这些途径可以相互合作，促进，对抗或相互作用，从而形成一个复杂的调控网络。该网络的功能障碍可能会增加甲状腺癌的发生，发展，侵袭和转移。不能手术的甲状腺癌预后仍然很差。但是，与信号通路相关的靶向疗法为这一小部分患者提供了更长的有意义的生活质量的希望。信号通路相关靶标为这种癌症的新治疗策略的进一步研究和临床开发提供了前所未有的机会。在目前的工作中，对这些信号通路和甲状腺癌靶向治疗的进展进行了综述。 2016; 8（4）：284-296doi：http://dx.doi.org/10.14740/jocmr2480w

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