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首页> 外文期刊>Journal of Clinical Medicine Research >Seropositivity for West Nile Virus Antibodies in Patients Affected by Myasthenia Gravis
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Seropositivity for West Nile Virus Antibodies in Patients Affected by Myasthenia Gravis

机译：重症肌无力患者西尼罗河病毒抗体的血清阳性

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Background: Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal muscles. Specific auto-antibodies against acetylcholine receptor (AChR) are present in the majority of MG patients, although the main cause behind its development still remains unclear. Recently MG development following West Nile virus (WNV) infection has been described in patients without any earlier evidence of MG. It is known that infectious agents trigger immune response and occasionally initiate autoimmune disease. WNV, the causative agent of both benign illness and neuroinvasive disease, has become endemic in many countries in all continents.Methods: In the present study, 29 patients (15 males and 14 females, 19 - 78 years old) with confirmed diagnosis of MG and elevated levels of AChR autoantibodies were screened for the presence of serum anti-WNV antibodies and compared to a similar population affected by different autoimmune diseases. Indirect immunofluorescent antibody technique was used to evaluate the reaction of patients’ sera on cells infected by WNV.Results: Positive fluorescent signals for anti-WNV IgG were obtained in 17% of MG patients, although no clinical manifestations related to WNV infection were reported. These results are in agreement with previous data and appear of great interest in the understanding of the pathogenic autoimmune mechanisms at the bases of MG development.Conclusion: As already observed in other human autoimmune diseases, pathogen-triggered autoimmunity could be involved in MG by breaking immunological self-tolerance through possible mechanisms of molecular mimicry between virus proteins and AChR subunits. In predisposed individuals, WNV infection could also represent an additional risk factor to initiate MG.J Clin Med Res. 2016;8(3):196-201doi: http://dx.doi.org/10.14740/jocmr2413w
机译：背景：重症肌无力（MG）是一种自身免疫性神经肌肉疾病，其特征是骨骼肌无力程度不同。大多数MG患者中都存在针对乙酰胆碱受体（AChR）的特异性自身抗体，尽管其发展的主要原因仍不清楚。在没有任何早期MG证据的患者中，最近描述了西尼罗河病毒（WNV）感染后MG的发展。已知感染因子触发免疫反应并偶尔引发自身免疫性疾病。 WNV是良性疾病和神经侵袭性疾病的致病因素，已在各大洲的许多国家流行。方法：在本研究中，确诊为MG的29例患者（男性15例，女性14例，年龄19-78岁）针对血清抗WNV抗体的存在筛选AChR抗体和水平升高的AChR自身抗体，并将其与受不同自身免疫性疾病影响的相似人群进行比较。结果：尽管17例重症肌无力患者中未见与WNV感染相关的临床表现，但17％的MG患者获得了抗WNV IgG阳性荧光信号。这些结果与以前的数据一致，并且对理解MG发展的基础上的致病性自身免疫机制表现出极大的兴趣。结论：正如在其他人类自身免疫性疾病中已经观察到的那样，病原体触发的自身免疫可能通过破坏MG而参与通过病毒蛋白和AChR亚基之间分子模仿的可能机制实现免疫自耐受。在易感人群中，WNV感染也可能是引发MG的另一个危险因素。 2016; 8（3）：196-201doi：http://dx.doi.org/10.14740/jocmr2413w

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