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首页> 外文期刊>Journal of Clinical Medicine Research >Is It Possible to Prevent Ovarian Hyperstimulation Syndrome by Gonadotropin-Releasing Hormone Agonist Triggering and Modified Luteal Support in Patients With Polycystic Ovarian Morphology?
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Is It Possible to Prevent Ovarian Hyperstimulation Syndrome by Gonadotropin-Releasing Hormone Agonist Triggering and Modified Luteal Support in Patients With Polycystic Ovarian Morphology?

机译：多囊卵巢形态学患者是否可以通过促性腺激素释放激素激动剂的触发和改良的黄体支持来预防卵巢过度刺激综合征？

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Background: Gonadotropin-releasing hormone (GnRH) agonist triggering plus 1,500 IU human chorionic gonadotropin (hCG) supplementation protocol was previously claimed effective in reducing the ovarian hyperstimulation syndrome (OHSS) incidence in high responders.Methods: This retrospective study included women with polycystic ovarian (PCO) morphology who were at high risk of OHSS and were given the GnRH agonist trigger plus hCG luteal support protocol in a single center.Results: The mean peak estradiol level was 5,336 ± 2,341 (1,187 - 19,746) pg/mL. The mean number of follicles > 12 mm on the day of trigger was 22 ± 7 (9 - 51). A total of 88 cycles were undertaken. Sixty-three (71.5%) women underwent fresh embryo transfer. Fresh embryo transfer was canceled in 21 (23.8%) and embryo transfer was canceled in four (4.5%) women. The overall clinical pregnancy rate was 46.4% per started cycle. A total of 12 (13.6%) patients developed OHSS. “Freeze-all” policy did not attenuate OHSS in four patients, and three of these patients developed OHSS despite 1,500 IU hCG was not administered.Conclusion: We conclude that OHSS may still occur with the use of a GnRH agonist trigger combined with low-dose hCG supplementation protocol in women with polycystic ovary syndrome (PCOS) or PCO morphology. Furthermore, we also conclude that “freeze-all” policy also will not completely eliminate OHSS development in high-risk women.J Clin Med Res. 2016;8(5):396-401doi: http://dx.doi.org/10.14740/jocmr2500w
机译：背景：促性腺激素释放激素（GnRH）激动剂触发加1,500 IU人绒毛膜促性腺激素（hCG）补充方案先前被认为可有效降低高反应者的卵巢过度刺激综合征（OHSS）发生率。方法：这项回顾性研究包括多囊卵巢的女性（PCO）高OHSS风险的形态，并在单个中心接受GnRH激动剂触发和hCG黄体支持方案。结果：雌二醇的平均峰值水平为5,336±2,341（1,187-19,746）pg / mL。触发当天，平均> 12 mm的卵泡数为22±7（9-51）。总共进行了88个循环。六十三（71.5％）名妇女接受了新鲜的胚胎移植。新鲜胚胎移植被取消21（23.8％），而胚胎移植被取消的四（4.5％）妇女。每个开始周期的总体临床妊娠率为46.4％。共有12名（13.6％）患者出现了OHSS。 “全部冻结”政策并没有减弱4例患者的OHSS，尽管未给予1,500 IU hCG，其中3例仍发生了OHSS。多囊卵巢综合征（PCOS）或PCO形态学女性的剂量hCG补充方案。此外，我们还得出结论，“全部冻结”政策也不会完全消除高风险女性的OHSS的发展。 2016; 8（5）：396-401doi：http://dx.doi.org/10.14740/jocmr2500w

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