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Factors Affecting Uptake of NaF-18 by the Normal Skeleton

机译：影响正常骨骼摄取NaF-18的因素

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Background: The primary aim of this study was to examine if factors such as renal function, height, weight and age could affect the uptake of sodium fluoride-18 (NaF-18) by the normal bone. This is the first study to examine the possible factors that can influence NaF-18 uptake in the normal bone. Methods: A retrospective study was done on NaF-18 PET/CT bone scans from January 2010 to May 2012 at our institution. All NaF-18 PET/CT studies used the same clinical protocol. Our excluding criteria were patients with abnormal renal function and patients with past history of cancer and metabolic bone diseases. Spearman’s correlation was used to analyze the data. Results: From our study (n = 11 patients), no correlation was found between SUVmax and serum creatinine and between SUVmax and age. However, significant correlations were found between SUVmax and height (cm) and between SUVmax and weight (kg) for thoracic 5, 7, 12 and lumbar 2 vertebral levels. Conclusion: Based on our findings, SUVmax values in NaF-18 PET/CT bone scans can vary depending on the patient’s height, weight and bone region. This information can be helpful in diagnosing and monitoring bone pathologies and can help explain the clinical findings.J Clin Med Res. 2014;6(6):435-442doi: http://dx.doi.org/10.14740/jocmr1901w
机译：背景：这项研究的主要目的是检查诸如肾功能，身高，体重和年龄等因素是否会影响正常骨骼对氟化钠18（NaF-18）的摄取。这是第一个研究可能影响正常骨骼中NaF-18摄取的因素的研究。方法：回顾性研究从2010年1月至2012年5月在我们机构进行的NaF-18 PET / CT骨扫描。所有NaF-18 PET / CT研究均使用相同的临床方案。我们排除的标准是肾功能异常的患者以及过去有癌症和代谢性骨病史的患者。 Spearman的相关性用于分析数据。结果：根据我们的研究（n = 11例患者），没有发现SUVmax与血清肌酐之间以及SUVmax与年龄之间存在相关性。然而，发现在胸部5、7、12和腰2椎骨水平上SUVmax与身高（cm）以及SUVmax与体重（kg）之间存在显着相关性。结论：根据我们的发现，NaF-18 PET / CT骨扫描中的SUVmax值可能会因患者的身高，体重和骨骼区域而异。该信息有助于诊断和监测骨病理，并有助于解释临床发现。 2014; 6（6）：435-442doi：http://dx.doi.org/10.14740/jocmr1901w

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